Anti-IFRD1 Antibody (CAB13318)
- SKU:
- CAB13318
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-IFRD1 Antibody |
| Antibody SKU: | CAB13318 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human IFRD1 (NP_001541.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW480 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human IFRD1 (NP_001541.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPKN KKRN TPHR GSSA GGGG SGAA AATA ATAG GQHR NVQP FSDE DASI ETMS HCSG YSDP SSFA EDGP EVLD EEGT QEDL EYKL KGLI DLTL DKSA KTRQ AALE GIKN ALAS KMLY EFIL ERRM TLTD SIER CLKK GKSD EQRA AAAL ASVL CIQL GPGI ESEE ILKT LGPI LKKI ICDG SASM QARQ TCAT CFGV CCFI ATDD ITEL YSTL ECLE NIFT KSYL KEKD TTVI CSTP NTVL |
| Gene ID: | 3475 |
| Uniprot: | O00458 |
| Cellular Location: | |
| Calculated MW: | 45kDa/50kDa |
| Observed MW: | 47kDa |
| Synonyms: | IFRD1, PC4, TIS7 |
| Background: | This gene is an immediate early gene that encodes a protein related to interferon-gamma. This protein may function as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration. Mutations in this gene are associated with sensory/motor neuropathy with ataxia. This gene may also be involved in modulating the pathogenesis of cystic fibrosis lung disease. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | IFRD1: Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal. Belongs to the IFRD family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 7q31.1 Cellular Component: nucleus Biological Process: multicellular organismal development; adult somatic muscle development; myoblast cell fate determination |
| NCBI Summary: | This gene is an immediate early gene that encodes a protein related to interferon-gamma. This protein may function as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration. Mutations in this gene are associated with sensory/motor neuropathy with ataxia. This gene may also be involved in modulating the pathogenesis of cystic fibrosis lung disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010] |
| UniProt Code: | O00458 |
| NCBI GenInfo Identifier: | 68846516 |
| NCBI Gene ID: | 3475 |
| NCBI Accession: | O00458.4 |
| UniProt Secondary Accession: | O00458,O75234, Q5U013, Q9BVE4, B7Z5G1, |
| UniProt Related Accession: | O00458 |
| Molecular Weight: | 45,336 Da |
| NCBI Full Name: | Interferon-related developmental regulator 1 |
| NCBI Synonym Full Names: | interferon-related developmental regulator 1 |
| NCBI Official Symbol: | IFRD1 |
| NCBI Official Synonym Symbols: | PC4; TIS7 |
| NCBI Protein Information: | interferon-related developmental regulator 1; TPA induced sequence 7; pheochromocytoma cell-4; nerve growth factor-inducible protein PC4; 12-O-tetradecanoylphorbol-13-acetate-induced sequence 7 |
| UniProt Protein Name: | Interferon-related developmental regulator 1 |
| UniProt Synonym Protein Names: | Nerve growth factor-inducible protein PC4 |
| Protein Family: | Interferon-related developmental regulator |
| UniProt Gene Name: | IFRD1 |
| UniProt Entry Name: | IFRD1_HUMAN |
 | Western blot analysis of extracts of SW480 cells, using IFRD1 antibody (CAB13318) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of A549 cells using IFRD1 antibody (CAB13318). |
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