Anti-IDO1 Antibody (CAB12125)
- SKU:
- CAB12125
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- IDO
- IDO-1
- INDO
Description
| Product Name: | IDO1 Rabbit mAb |
| Product Code: | CAB12125 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | IDO, IDO-1, INDO |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human IDO1 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse ovary |
| Immunogen: | A synthesized peptide derived from human IDO1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3620 |
| Uniprot: | P14902 |
| Calculated MW: | 45kDa |
| Observed MW: | 42KDa |
| UniProt Protein Function: | INDO: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. Belongs to the indoleamine 2,3-dioxygenase family. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - tryptophan; Cell cycle regulation; EC 1.13.11.52; Oxidoreductase Chromosomal Location of Human Ortholog: 8p12-p11 Cellular Component: stereocilium bundle; smooth muscle contractile fiber; cytosol Molecular Function:electron carrier activity; metal ion binding; heme binding; indoleamine 2,3-dioxygenase activity; tryptophan 2,3-dioxygenase activity Biological Process: regulation of activated T cell proliferation; positive regulation of T-helper 2 type immune response; negative regulation of interleukin-10 production; positive regulation of chronic inflammatory response; tryptophan catabolic process to kynurenine; positive regulation of interleukin-12 production; response to lipopolysaccharide; female pregnancy; negative regulation of T cell proliferation; cytokine production during acute inflammatory response; multicellular organismal response to stress; tryptophan catabolic process; positive regulation of T cell tolerance induction |
| NCBI Summary: | This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011] |
| UniProt Code: | P14902 |
| NCBI GenInfo Identifier: | 123948 |
| NCBI Gene ID: | 3620 |
| NCBI Accession: | P14902.1 |
| UniProt Related Accession: | P14902 |
| Molecular Weight: | 45kDa |
| NCBI Full Name: | Indoleamine 2,3-dioxygenase 1 |
| NCBI Synonym Full Names: | indoleamine 2,3-dioxygenase 1 |
| NCBI Official Symbol: | IDO1 |
| NCBI Official Synonym Symbols: | IDO; INDO; IDO-1 |
| NCBI Protein Information: | indoleamine 2,3-dioxygenase 1 |
| UniProt Protein Name: | Indoleamine 2,3-dioxygenase 1 |
| UniProt Synonym Protein Names: | Indoleamine-pyrrole 2,3-dioxygenase |
| Protein Family: | L-isoleucine-4-hydroxylase |
| UniProt Gene Name: | IDO1 |
| UniProt Entry Name: | I23O1_HUMAN |
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