Anti-IBSP Antibody (CAB16220)
- SKU:
- CAB16220
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-IBSP Antibody |
| Antibody SKU: | CAB16220 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IBSP (NP_004958.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IBSP (NP_004958.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKTA LILL SILG MACA FSMK NLHR RVKI EDSE ENGV FKYR PRYY LYKH AYFY PHLK RFPV QGSS DSSE ENGD DSSE EEEE EEET SNEG ENNE ESNE DEDS |
| Gene ID: | 3381 |
| Uniprot: | P21815 |
| Cellular Location: | Secreted |
| Calculated MW: | 35kDa |
| Observed MW: | Refer to figures |
| Synonyms: | IBSP, BNSP, BSP, BSP-II, SP-II |
| Background: | The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. |
| UniProt Protein Function: | Sialoprotein-2: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Cell adhesion; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 4q21.1 Cellular Component: extracellular space; membrane; extracellular region Biological Process: osteoblast differentiation; extracellular matrix organization and biogenesis; biomineral formation; cell adhesion |
| NCBI Summary: | The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P21815 |
| NCBI GenInfo Identifier: | 317373545 |
| NCBI Gene ID: | 3381 |
| NCBI Accession: | P21815.4 |
| UniProt Related Accession: | P21815 |
| Molecular Weight: | 35,148 Da |
| NCBI Full Name: | Bone sialoprotein 2 |
| NCBI Synonym Full Names: | integrin-binding sialoprotein |
| NCBI Official Symbol: | IBSP |
| NCBI Official Synonym Symbols: | BSP; BNSP; SP-II; BSP-II |
| NCBI Protein Information: | bone sialoprotein 2; BSP II; bone sialoprotein II; cell-binding sialoprotein |
| UniProt Protein Name: | Bone sialoprotein 2 |
| UniProt Synonym Protein Names: | Bone sialoprotein II; BSP II; Cell-binding sialoprotein; Integrin-binding sialoprotein |
| Protein Family: | Bone sialoprotein |
| UniProt Gene Name: | IBSP |
| UniProt Entry Name: | SIAL_HUMAN |
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Mouse Bone sialoprotein 2 (Ibsp) ELISA Kit
Human Bone sialoprotein 2 (IBSP) ELISA Kit
