Anti-HVEM/TNFRSF14 Antibody (CAB1969)
- SKU:
- CAB1969
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
| Antibody Name: | Anti-HVEM/TNFRSF14 Antibody |
| Antibody SKU: | CAB1969 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 39-202 of human HVEM/TNFRSF14 (NP_003811.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | Raji |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 39-202 of human HVEM/TNFRSF14 (NP_003811.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LPSC KEDE YPVG SECC PKCS PGYR VKEA CGEL TGTV CEPC PPGT YIAH LNGL SKCL QCQM CDPA MGLR ASRN CSRT ENAV CGCS PGHF CIVQ DGDH CAAC RAYA TSSP GQRV QKGG TESQ DTLC QNCP PGTF SPNG TLEE CQHQ TKCS WLVT KAGA GTSS SHWV |
| Gene ID: | 8764 |
| Uniprot: | Q92956 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 21kDa/30kDa |
| Observed MW: | 30kDa |
| Synonyms: | TNFRSF14, ATAR, CD270, HVEA, HVEM, LIGHTR, TR2 |
| Background: | This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | TNFRSF14: Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral; Cell cycle regulation Chromosomal Location of Human Ortholog: 1p36.32 Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane Molecular Function:viral receptor activity; protein binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding Biological Process: positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-positive bacterium; entry of virus into host cell; cell surface receptor linked signal transduction; tumor necrosis factor-mediated signaling pathway; T cell costimulation; positive regulation of cytokine secretion during immune response; negative regulation of alpha-beta T cell proliferation; immune response; defense response to Gram-negative bacterium |
| NCBI Summary: | This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q92956 |
| NCBI GenInfo Identifier: | 13878821 |
| NCBI Gene ID: | 8764 |
| NCBI Accession: | Q92956.3 |
| UniProt Secondary Accession: | Q92956,Q6IB95, Q8N634, Q8WXR1, Q96J31, Q9UM65, B3KW30 B9DI89, |
| UniProt Related Accession: | Q92956 |
| Molecular Weight: | 283 |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member 14 |
| NCBI Synonym Full Names: | tumor necrosis factor receptor superfamily, member 14 |
| NCBI Official Symbol: | TNFRSF14 |
| NCBI Official Synonym Symbols: | TR2; ATAR; HVEA; HVEM; CD270; LIGHTR |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 14; CD40-like protein; herpes virus entry mediator A; tumor necrosis factor receptor-like gene2; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 14 |
| UniProt Synonym Protein Names: | Herpes virus entry mediator A; Herpesvirus entry mediator A; HveA; Tumor necrosis factor receptor-like 2; TR2; CD_antigen: CD270 |
| Protein Family: | Tumor necrosis factor receptor superfamily |
| UniProt Gene Name: | TNFRSF14 |
| UniProt Entry Name: | TNR14_HUMAN |
 | Western blot analysis of extracts of Raji cells, using HVEM/TNFRSF14 antibody (CAB1969) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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