Anti-Human IL-4 In Vivo Antibody - Low Endotoxin

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SKU:
IVMB0003
Product Type:
In Vivo Monoclonal Antibody
Clone:
MP4-25D2
Protein:
IL-4
Isotype:
Rat IgG1 kappa
Reactivity:
Human
Synonyms:
BCGF
BCDF
B Cell Stimulating Factor
BSF-1
Endotoxin Level:
Low Endotoxin
Host Species:
Rat
Applications:
CyTOF
IHC
Neutralizing
WB
Frequently bought together:

Description

system_update_altTechnical Datasheet
Product Name:Anti-Human IL-4 In Vivo Antibody - Low Endotoxin
Product Code:IVMB0003
Size:1mg, 5mg, 25mg, 50mg, 100mg
Clone:MP4-25D2
Protein:IL-4
Product Type:Monoclonal Antibody
Synonyms:BCGF, BCDF, B Cell Stimulating Factor, BSF-1
Isotype:Rat IgG1 κ
Reactivity:Human
Immunogen:CHO-expressed, recombinant human IL-4
Applications:CyTOF®, IHC, N, WB
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Endotoxin Level:< 1.0 EU/mg as determined by the LAL method
Purity:≥95% monomer by analytical SEC
>95% by SDS Page
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Applications:CyTOF®, IHC, N, WB
Recommended Usage:ELISA
Each lot of this antibody is quality control tested by ELISA.
Reactivity:Human
Host Species:Rat
Specificity:Clone MP4-25D2 recognizes human IL-4.
Immunogen:CHO-expressed, recombinant human IL-4
Concentration:≥ 2.0 mg/ml
Endotoxin Level:< 1.0 EU/mg as determined by the LAL method
Purity:≥95% monomer by analytical SEC
>95% by SDS Page
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

IL-4 is a 15-19 kD pleiotropic immune cytokine secreted by activated TH2 cells. It has many biological roles, including the regulation in humoral and adaptive immunity, the inhibition of bone resorption, the stimulation of activated B-cell and T-cell proliferation, and initiation of allergic responses. Moreover, IL-4 induces a positive feedback loop by stimulating differentiation of naive helper T cells, or Th0 cells, to Th2 cells which in turn secrete more IL-4. Increased IL-4 production and overproduction of IL-4R are found in many cancers. IL-4 has a significant effect on tumor progression by increasing apoptosis resistance via tumor growth enhancement. IL-4 may also play a part in the immune dysregulation that occurs in most HIV-1 infected patients.

Technical Datasheet:View
Protein:IL-4
Research Area:Cell Biology, Immunology, Neuroinflammation, Neuroscience
Product Thumbnail
Rat IgG1 Isotype Control
Clone GL113
Isotype Rat IgG1
Endotoxin Level Low Endotoxin
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