Anti-HTR1A Antibody (CAB2801)
- SKU:
- CAB2801
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-HTR1A Antibody |
| Antibody SKU: | CAB2801 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human HTR1A |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, SH-SY5Y, Mouse testis, Rat testis |
| Immunogen: | A synthetic peptide of human HTR1A |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3350 |
| Uniprot: | P08908 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 46kDa |
| Observed MW: | 46kDa |
| Synonyms: | G-21, 5HT1a, PFMCD, 5-HT1A, 5-HT-1A, ADRBRL1, ADRB2RL1, HTR1A |
| Background: | This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. |
| UniProt Protein Function: | 5-HT(1A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1 Chromosomal Location of Human Ortholog: 5q11.2-q13 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:protein binding; serotonin receptor activity Biological Process: vasoconstriction; G-protein coupled receptor protein signaling pathway; cell proliferation; behavioral fear response; serotonin receptor, adenylate cyclase inhibiting pathway; regulation of dopamine metabolic process; regulation of serotonin secretion; positive regulation of cell proliferation; regulation of hormone secretion; serotonin receptor signaling pathway; serotonin metabolic process; regulation of behavior Disease: Periodic Fever, Menstrual Cycle-dependent |
| NCBI Summary: | This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012] |
| UniProt Code: | P08908 |
| NCBI GenInfo Identifier: | 231454 |
| NCBI Gene ID: | 3350 |
| NCBI Accession: | P08908.3 |
| UniProt Secondary Accession: | P08908,Q6LAE7, |
| UniProt Related Accession: | P08908 |
| Molecular Weight: | |
| NCBI Full Name: | 5-hydroxytryptamine receptor 1A |
| NCBI Synonym Full Names: | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled |
| NCBI Official Symbol: | HTR1A |
| NCBI Official Synonym Symbols: | G-21; 5HT1a; PFMCD; 5-HT1A; 5-HT-1A; ADRBRL1; ADRB2RL1 |
| NCBI Protein Information: | 5-hydroxytryptamine receptor 1A; 5-HT1a receptor; guanine nucleotide-binding regulatory protein-coupled receptor |
| UniProt Protein Name: | 5-hydroxytryptamine receptor 1A |
| UniProt Synonym Protein Names: | G-21; Serotonin receptor 1A |
| Protein Family: | 5-hydroxytryptamine receptor |
| UniProt Gene Name: | HTR1A |
| UniProt Entry Name: | 5HT1A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HTR1A antibody (CAB2801) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 3min. |