Anti-HSPH1 Antibody (CAB6622)
- SKU:
- CAB6622
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-HSPH1 Antibody |
| Antibody SKU: | CAB6622 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 659-858 of human HSPH1 (NP_006635.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, BT-474, HepG2, 293T, U-251MG, Mouse brain, Mouse kidney, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 659-858 of human HSPH1 (NP_006635.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EQDH QNFL RLLT ETED WLYE EGED QAKQ AYVD KLEE LMKI GTPV KVRF QEAE ERPK MFEE LGQR LQHY AKIA ADFR NKDE KYNH IDES EMKK VEKS VNEV MEWM NNVM NAQA KKSL DQDP VVRA QEIK TKIK ELNN TCEP VVTQ PKPK IESP KLER TPNG PNID KKEE DLED KNNF GAEP PHQN GECY PNEK NSVN MDLD |
| Gene ID: | 10808 |
| Uniprot: | Q92598 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 92kDa/96kDa/97kDa |
| Observed MW: | 120kDa |
| Synonyms: | HSPH1, HSP105, HSP105A, HSP105B, NY-CO-25 |
| Background: | This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. |
| UniProt Protein Function: | HSP105: a molecular chaperone of the heat shock protein 70 family. Has ATPase activity. Expressed at especially high levels in mammalian brain and has been shown to suppress apoptosis in neuronal cells and to prevent the aggregation of proteins following heat shock. Known to interact with a variety of proteins including alpha-tubulin and the androgen receptor. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Heat shock protein; Chaperone Chromosomal Location of Human Ortholog: 13q12.3 Cellular Component: nucleoplasm; microtubule; cytoplasm; extracellular region; cytosol Molecular Function:protein binding; ATP binding; alpha-tubulin binding Biological Process: receptor-mediated endocytosis; positive regulation of NK T cell activation; chaperone cofactor-dependent protein folding; positive regulation of MHC class I biosynthetic process; response to unfolded protein |
| UniProt Code: | Q92598 |
| NCBI GenInfo Identifier: | 2495344 |
| NCBI Gene ID: | 10808 |
| NCBI Accession: | Q92598.1 |
| UniProt Secondary Accession: | Q92598,O95739, Q5TBM6, Q5TBM7, Q5TBM8, Q9UPC4, B4DYH1 |
| UniProt Related Accession: | Q92598 |
| Molecular Weight: | 97,460 Da |
| NCBI Full Name: | Heat shock protein 105 kDa |
| NCBI Synonym Full Names: | heat shock 105kDa/110kDa protein 1 |
| NCBI Official Symbol: | HSPH1 |
| NCBI Official Synonym Symbols: | HSP105; HSP105A; HSP105B; NY-CO-25 |
| NCBI Protein Information: | heat shock protein 105 kDa; antigen NY-CO-25; heat shock 105kD beta; heat shock 105kD alpha |
| UniProt Protein Name: | Heat shock protein 105 kDa |
| UniProt Synonym Protein Names: | Antigen NY-CO-25; Heat shock 110 kDa protein |
| Protein Family: | Heat shock protein |
| UniProt Gene Name: | HSPH1 |
| UniProt Entry Name: | HS105_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HSPH1 antibody (CAB6622) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunohistochemistry of paraffin-embedded rat fallopian tube using HSPH1 antibody (CAB6622) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human tonsil using HSPH1 antibody (CAB6622) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spinal cord using HSPH1 antibody (CAB6622) at dilution of 1:100 (40x lens). |
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