Anti-Hsp90 alpha Antibody (CAB13501)

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SKU:
CAB13501
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
Frequently bought together:

Description

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Antibody Name:Anti-Hsp90 alpha Antibody
Antibody SKU:CAB13501
Antibody Size:20uL, 50uL, 100uL
Application:WB IP
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 433-732 of human Hsp90 alpha (NP_005339.3).
Application:WB IP
Recommended Dilution:WB 1:500 - 1:2000 IP 1:20 - 1:50
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, COS-1, COS-7, PC-12
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 433-732 of human Hsp90 alpha (NP_005339.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NYKK FYEQ FSKN IKLG IHED SQNR KKLS ELLR YYTS ASGD EMVS LKDY CTRM KENQ KHIY YITG ETKD QVAN SAFV ERLR KHGL EVIY MIEP IDEY CVQQ LKEF EGKT LVSV TKEG LELP EDEE EKKK QEEK KTKF ENLC KIMK DILE KKVE KVVV SNRL VTSP CCIV TSTY GWTA NMER IMKA QALR DNST MGYM AAKK HLEI NPDH SIIE TLRQ KAEA DKND KSVK DLVI LLYE TALL SSGF SLED PQTH ANRI YRMI KLGL GIDE DDPT ADDT SAAV TEEM PPLE GDDD TSRM EEVD
Gene ID:3320
Uniprot:P07900
Cellular Location:Cell membrane, Cytoplasm, Melanosome
Calculated MW:84kDa/98kDa
Observed MW:101kDa
Synonyms:HSP90AA1, EL52, HEL-S-65p, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp103, Hsp89, Hsp90, LAP-2, LAP2
Background:The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11274138, PubMed:11276205, PubMed:15577939, PubMed:15937123, PubMed:27353360).
NCBI Summary:The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Code:P07900
NCBI GenInfo Identifier:92090606
NCBI Gene ID:3320
NCBI Accession:P07900.5
UniProt Secondary Accession:P07900,Q2PP14, Q5CAQ6, Q5CAQ7, Q9BVQ5, A8K500, B3KPJ9
UniProt Related Accession:P07900
Molecular Weight:98,161 Da
NCBI Full Name:Heat shock protein HSP 90-alpha
NCBI Synonym Full Names:heat shock protein 90 alpha family class A member 1
NCBI Official Symbol:HSP90AA1  
NCBI Official Synonym Symbols:EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; Hsp103; HSPCAL1; HSPCAL4; HEL-S-65p  
NCBI Protein Information:heat shock protein HSP 90-alpha
UniProt Protein Name:Heat shock protein HSP 90-alpha
UniProt Synonym Protein Names:Heat shock 86 kDa; HSP 86; HSP86; Lipopolysaccharide-associated protein 2; LAP-2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38
Protein Family:Heat shock protein
UniProt Gene Name:HSP90AA1  
Anti-Hsp90 alpha Antibody (CAB13501)Western blot analysis of extracts of various cell lines, using HSP90AA1 antibody (CAB13501) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-Hsp90 alpha Antibody (CAB13501)Immunoprecipitation analysis of 200ug extracts of HeLa cells using 1ug HSP90AA1 antibody (CAB13501). Western blot was performed from the immunoprecipitate using HSP90AA1 antibody (CAB13501) at a dilition of 1:500.

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