Anti-Hsp105 Antibody (CAB4687)
- SKU:
- CAB4687
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-Hsp105 Antibody |
| Antibody SKU: | CAB4687 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Hsp105 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, HepG2, PC-3, Mouse brain, Rat brain |
| Immunogen: | A synthesized peptide derived from human Hsp105 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10808 |
| Uniprot: | Q92598 |
| Cellular Location: | |
| Calculated MW: | 105kDa |
| Observed MW: | 105KDa |
| Synonyms: | HSP105, HSP105A, HSP105B, NY-CO-25 |
| Background: | This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017] |
| UniProt Protein Function: | HSP105: a molecular chaperone of the heat shock protein 70 family. Has ATPase activity. Expressed at especially high levels in mammalian brain and has been shown to suppress apoptosis in neuronal cells and to prevent the aggregation of proteins following heat shock. Known to interact with a variety of proteins including alpha-tubulin and the androgen receptor. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Heat shock protein; Chaperone Chromosomal Location of Human Ortholog: 13q12.3 Cellular Component: nucleoplasm; microtubule; cytoplasm; extracellular region; cytosol Molecular Function:protein binding; ATP binding; alpha-tubulin binding Biological Process: receptor-mediated endocytosis; positive regulation of NK T cell activation; chaperone cofactor-dependent protein folding; positive regulation of MHC class I biosynthetic process; response to unfolded protein |
| UniProt Code: | Q92598 |
| NCBI GenInfo Identifier: | 2495344 |
| NCBI Gene ID: | 10808 |
| NCBI Accession: | Q92598.1 |
| UniProt Secondary Accession: | Q92598,O95739, Q5TBM6, Q5TBM7, Q5TBM8, Q9UPC4, B4DYH1 |
| UniProt Related Accession: | Q92598 |
| Molecular Weight: | 97,460 Da |
| NCBI Full Name: | Heat shock protein 105 kDa |
| NCBI Synonym Full Names: | heat shock 105kDa/110kDa protein 1 |
| NCBI Official Symbol: | HSPH1 |
| NCBI Official Synonym Symbols: | HSP105; HSP105A; HSP105B; NY-CO-25 |
| NCBI Protein Information: | heat shock protein 105 kDa; antigen NY-CO-25; heat shock 105kD beta; heat shock 105kD alpha |
| UniProt Protein Name: | Heat shock protein 105 kDa |
| UniProt Synonym Protein Names: | Antigen NY-CO-25; Heat shock 110 kDa protein |
| Protein Family: | Heat shock protein |
| UniProt Gene Name: | HSPH1 |
| UniProt Entry Name: | HS105_HUMAN |
 | Western blot - Hsp105 Rabbit mAb (CAB4687) |
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