Anti-HSD17B6 Antibody (CAB14262)
- SKU:
- CAB14262
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-HSD17B6 Antibody |
| Antibody SKU: | CAB14262 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 178-317 of human HSD17B6 (NP_003716.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 178-317 of human HSD17B6 (NP_003716.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VSKY GVEA FSDI LRRE IQHF GVKI SIVE PGYF RTGM TNMT QSLE RMKQ SWKE APKH IKET YGQQ YFDA LYNI MKEG LLNC STNL NLVT DCME HALT SVHP RTRY SAGW DAKF FFIP LSYL PTSL ADYI LTRS WPKP AQAV |
| Gene ID: | 8630 |
| Uniprot: | O14756 |
| Cellular Location: | Early endosome membrane, Lumenal side, Microsome membrane, Peripheral membrane protein |
| Calculated MW: | 35kDa |
| Observed MW: | Refer to Figures |
| Synonyms: | HSD17B6, HSE, RODH, SDR9C6 |
| Background: | The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. |
| UniProt Protein Function: | HSD17B6: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha- androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids. Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.1.1.239; EC 1.1.1.105; EC 1.1.1.62 Chromosomal Location of Human Ortholog: 12q13 Cellular Component: endoplasmic reticulum; early endosome membrane; intracellular Molecular Function:estradiol 17-beta-dehydrogenase activity; electron carrier activity; oxidoreductase activity; catalytic activity; 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity; retinol dehydrogenase activity Biological Process: androgen biosynthetic process; androgen catabolic process |
| NCBI Summary: | The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. [provided by RefSeq, Aug 2013] |
| UniProt Code: | O14756 |
| NCBI GenInfo Identifier: | 74739479 |
| NCBI Gene ID: | 8630 |
| NCBI Accession: | O14756.1 |
| UniProt Related Accession: | O14756 |
| Molecular Weight: | 36kDa |
| NCBI Full Name: | 17-beta-hydroxysteroid dehydrogenase type 6 |
| NCBI Synonym Full Names: | hydroxysteroid 17-beta dehydrogenase 6 |
| NCBI Official Symbol: | HSD17B6 |
| NCBI Official Synonym Symbols: | HSE; RODH; SDR9C6 |
| NCBI Protein Information: | 17-beta-hydroxysteroid dehydrogenase type 6 |
| UniProt Protein Name: | 17-beta-hydroxysteroid dehydrogenase type 6 |
| UniProt Synonym Protein Names: | 3-alpha->beta-hydroxysteroid epimerase; 3-alpha->beta-HSE; Oxidative 3-alpha hydroxysteroid dehydrogenase |
| Protein Family: | 17-beta-hydroxysteroid dehydrogenase |
| UniProt Gene Name: | HSD17B6 |
| UniProt Entry Name: | H17B6_HUMAN |
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