Anti-HSD17B2 Antibody (CAB1983)
- SKU:
- CAB1983
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-HSD17B2 Antibody |
| Antibody SKU: | CAB1983 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 118-387 of human HSD17B2 (NP_002144.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW480, Mouse liver, Mouse kidney, Mouse craniofacial, Mouse intestine |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 118-387 of human HSD17B2 (NP_002144.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GPGA EELR RTCS PRLS VLQM DITK PVQI KDAY SKVA AMLQ DRGL WAVI NNAG VLGF PTDG ELLL MTDY KQCM AVNF FGTV EVTK TFLP LLRK SKGR LVNV SSMG GGAP MERL ASYG SSKA AVTM FSSV MRLE LSKW GIKV ASIQ PGGF LTNI AGTS DKWE KLEK DILD HLPA EVQE DYGQ DYIL AQRN FLLL INSL ASKD FSPV LRDI QHAI LAKS PFAY YTPG KGAY LWIC LAHY LPIG IYDY FAKR HFGQ DKPM PRAL RMPN YKKK AT |
| Gene ID: | 3294 |
| Uniprot: | P37059 |
| Cellular Location: | Membrane, Single-pass type II membrane protein |
| Calculated MW: | 42kDa |
| Observed MW: | 47kDa |
| Synonyms: | HSD17B2, EDH17B2, HSD17, SDR9C2 |
| Background: |
| UniProt Protein Function: | HSD17B2: Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH. Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.1.1.239; Endoplasmic reticulum; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; EC 1.1.1.62 Chromosomal Location of Human Ortholog: 16q24.1-q24.2 Cellular Component: endoplasmic reticulum membrane Molecular Function:20-alpha-hydroxysteroid dehydrogenase activity; 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity; estradiol 17-beta-dehydrogenase activity Biological Process: response to retinoic acid |
| UniProt Code: | P37059 |
| NCBI GenInfo Identifier: | 544152 |
| NCBI Gene ID: | 3294 |
| NCBI Accession: | P37059.1 |
| UniProt Secondary Accession: | P37059,B2R7T4, |
| UniProt Related Accession: | P37059 |
| Molecular Weight: | 42,785 Da |
| NCBI Full Name: | Estradiol 17-beta-dehydrogenase 2 |
| NCBI Synonym Full Names: | hydroxysteroid 17-beta dehydrogenase 2 |
| NCBI Official Symbol: | HSD17B2 |
| NCBI Official Synonym Symbols: | HSD17; SDR9C2; EDH17B2 |
| NCBI Protein Information: | estradiol 17-beta-dehydrogenase 2 |
| UniProt Protein Name: | Estradiol 17-beta-dehydrogenase 2 |
| UniProt Synonym Protein Names: | 17-beta-hydroxysteroid dehydrogenase type 2; 17-beta-HSD 2; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; Microsomal 17-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 9C member 2; Testosterone 17-beta-dehydrogenase (EC:1.1.1.239) |
| Protein Family: | Estradiol 17 beta-dehydrogenase |
| UniProt Gene Name: | HSD17B2 |
| UniProt Entry Name: | DHB2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HSD17B2 antibody (CAB1983) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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