Anti-HS3ST3A1 Antibody (CAB16474)
- SKU:
- CAB16474
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-HS3ST3A1 Antibody |
| Antibody SKU: | CAB16474 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 44-140 of human HS3ST3A1 (NP_006033.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-251MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 44-140 of human HS3ST3A1 (NP_006033.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ERCQ TLSG PVVG LSGG GEEA GAPG GGVL AGGP RELA VWPA AAQR KRLL QLPQ WRRR RPPA PRDD GEEA AWEE ESPG LSGG PGGS GAGS TVAE APPG T |
| Gene ID: | 9955 |
| Uniprot: | Q9Y663 |
| Cellular Location: | Golgi apparatus membrane, Single-pass type II membrane protein |
| Calculated MW: | 44kDa |
| Observed MW: | 45kDa |
| Synonyms: | HS3ST3A1, 3-OST-3A, 3OST3A1 |
| Background: | Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta. |
| UniProt Protein Function: | HS3ST3A1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non- anticoagulant heparan sulfate to anticoagulant heparan sulfate. Belongs to the sulfotransferase 1 family. |
| UniProt Protein Details: | Protein type:Glycan Metabolism - heparan sulfate biosynthesis; Membrane protein, integral; EC 2.8.2.23; Glycan Metabolism - glycosaminoglycan degradation; Transferase Chromosomal Location of Human Ortholog: 17p12 Cellular Component: Golgi membrane; integral to membrane Molecular Function:[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity; sulfotransferase activity Biological Process: glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; pathogenesis |
| NCBI Summary: | Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y663 |
| NCBI GenInfo Identifier: | 61214551 |
| NCBI Gene ID: | 9955 |
| NCBI Accession: | Q9Y663.1 |
| UniProt Secondary Accession: | Q9Y663,A8K7N2, |
| UniProt Related Accession: | Q9Y663 |
| Molecular Weight: | |
| NCBI Full Name: | Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 |
| NCBI Synonym Full Names: | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 |
| NCBI Official Symbol: | HS3ST3A1 |
| NCBI Official Synonym Symbols: | 30ST3A1; 3OST3A1 |
| NCBI Protein Information: | heparan sulfate glucosamine 3-O-sulfotransferase 3A1; 3-OST-3A; h3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparin-glucosamine 3-O-sulfotransferase; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1 |
| UniProt Protein Name: | Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 |
| UniProt Synonym Protein Names: | Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1 |
| Protein Family: | Heparan sulfate glucosamine 3-O-sulfotransferase |
| UniProt Gene Name: | HS3ST3A1 |
| UniProt Entry Name: | HS3SA_HUMAN |
 | Western blot analysis of extracts of U-251MG cells, using HS3ST3A1 antibody (CAB16474) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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