Anti-HPRT Antibody (CAB8783)
- SKU:
- CAB8783
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-HPRT Antibody |
| Antibody SKU: | CAB8783 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human HPRT |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, NIH/3T3, Mouse brain, Mouse heart, Rat heart, Rat thymus |
| Immunogen: | A synthesized peptide derived from human HPRT |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3251 |
| Uniprot: | P00492 |
| Cellular Location: | |
| Calculated MW: | 25kDa |
| Observed MW: | 25KDa |
| Synonyms: | HGPRT, HPRT |
| Background: | The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.[provided by RefSeq, Jun 2009] |
| UniProt Protein Function: | HPRT1: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. Defects in HPRT1 are the cause of Lesch-Nyhan syndrome (LNS). LNS is characterized by complete lack of enzymatic activity that results in hyperuricemia, choreoathetosis, mental retardation, and compulsive self-mutilation. Defects in HPRT1 are the cause of gout HPRT-related (GOUT-HPRT); also known as HPRT-related gout or Kelley-Seegmiller syndrome. Gout is characterized by partial enzyme activity and hyperuricemia. Belongs to the purine/pyrimidine phosphoribosyltransferase family. |
| UniProt Protein Details: | Protein type:EC 2.4.2.8; Xenobiotic Metabolism - drug metabolism - other enzymes; Transferase; Nucleotide Metabolism - purine; Cell development/differentiation Chromosomal Location of Human Ortholog: Xq26.1 Cellular Component: cytoplasm; cytosol Molecular Function:protein binding; protein homodimerization activity; hypoxanthine phosphoribosyltransferase activity; magnesium ion binding; nucleotide binding Biological Process: grooming behavior; lymphocyte proliferation; hypoxanthine metabolic process; IMP salvage; striatum development; nucleobase, nucleoside and nucleotide metabolic process; GMP salvage; dendrite morphogenesis; cytolysis; response to amphetamine; locomotory behavior; adenine salvage; purine nucleotide biosynthetic process; dopamine metabolic process; purine base metabolic process; purine salvage; cerebral cortex neuron differentiation; protein homotetramerization; positive regulation of dopamine metabolic process; GMP catabolic process; IMP metabolic process; hypoxanthine salvage; purine ribonucleoside salvage; central nervous system neuron development; guanine salvage Disease: Kelley-seegmiller Syndrome; Lesch-nyhan Syndrome |
| NCBI Summary: | The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.[provided by RefSeq, Jun 2009] |
| UniProt Code: | P00492 |
| NCBI GenInfo Identifier: | 123497 |
| NCBI Gene ID: | 3251 |
| NCBI Accession: | P00492.2 |
| UniProt Secondary Accession: | P00492,A6NHF0, B2R8M9, |
| UniProt Related Accession: | P00492 |
| Molecular Weight: | 218 |
| NCBI Full Name: | Hypoxanthine-guanine phosphoribosyltransferase |
| NCBI Synonym Full Names: | hypoxanthine phosphoribosyltransferase 1 |
| NCBI Official Symbol: | HPRT1 |
| NCBI Official Synonym Symbols: | HPRT; HGPRT |
| NCBI Protein Information: | hypoxanthine-guanine phosphoribosyltransferase; HGPRTase |
| UniProt Protein Name: | Hypoxanthine-guanine phosphoribosyltransferase |
| Protein Family: | Hypoxanthine-guanine phosphoribosyltransferase |
| UniProt Gene Name: | HPRT1 |
| UniProt Entry Name: | HPRT_HUMAN |
 | Western blot - HPRT Rabbit mAb (CAB8783) |
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