Anti-HNRPAB Antibody (CAB17497)
- SKU:
- CAB17497
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| Antibody Name: | HNRPolyclonal Antibody Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB17497 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-285 of human HNRPAB (NP_004490.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-285 of human HNRPAB (NP_004490.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSEA GEEQ PMET TGAT ENGH EAVP EGES PAGA GTGA AAGA GGAT AAPP SGNQ NGAE GDQI NASK NEED AGKM FVGG LSWD TSKK DLKD YFTK FGEV VDCT IKMD PNTG RSRG FGFI LFKD AASV EKVL DQKE HRLD GRVI DPKK AMAM KKDP VKKI FVGG LNPE ATEE KIRE YFGE FGEI EAIE LPMD PKLN KRRG FVFI TFKE EEPV KKVL EKKF HTVS GSKC EIKV AQPK EVYQ QQQY GSGG RGNR NRGN RGSG GGGG GGGQ GSTN YGKS QRRG GHQN NYKP Y |
| Gene ID: | 3182 |
| Uniprot: | Q99729 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 37/41kDa |
 | Western blot - HNRPAB Polyclonal Antibody (CAB17497) |
| Synonyms: | ABBP1, HNRPAB, HNRNPAB |
| Background: | This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | hnRNP A/B: a single-stranded RNA binding protein with two RNA-recognition (RRM) domains. Has a high affinity for G- rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site. Interacts with APOBEC1. Observed in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. A member of the RNA recognition motif (RRM) family. Four isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 5q35.3 Cellular Component: nucleoplasm; cytoplasm; nucleus; ribonucleoprotein complex Molecular Function:mRNA binding; RNA binding; sequence-specific DNA binding; nucleotide binding; transcription factor activity Biological Process: positive regulation of transcription, DNA-dependent; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99729 |
| NCBI GenInfo Identifier: | 158523286 |
| NCBI Gene ID: | 3182 |
| NCBI Accession: | Q99729.2 |
| UniProt Related Accession: | Q99729 |
| Molecular Weight: | |
| NCBI Full Name: | Heterogeneous nuclear ribonucleoprotein A/B |
| NCBI Synonym Full Names: | heterogeneous nuclear ribonucleoprotein A/B |
| NCBI Official Symbol: | HNRNPAB |
| NCBI Official Synonym Symbols: | ABBP1; HNRPAB |
| NCBI Protein Information: | heterogeneous nuclear ribonucleoprotein A/B |
| UniProt Protein Name: | Heterogeneous nuclear ribonucleoprotein A/B |
| UniProt Synonym Protein Names: | APOBEC1-binding protein 1 |
| Protein Family: | Ribosomal operon-associated A protein |
| UniProt Gene Name: | HNRNPAB |
| UniProt Entry Name: | ROAA_HUMAN |
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