Anti-hnRNP U Antibody (CAB4257)
- SKU:
- CAB4257
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-hnRNP U Antibody |
| Antibody SKU: | CAB4257 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human hnRNP U |
| Application: | WB IHC IF IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | K-562, Mouse testis, Mouse brain, Rat testis |
| Immunogen: | A synthesized peptide derived from human hnRNP U |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3192 |
| Uniprot: | Q00839 |
| Cellular Location: | Cell surface, Cytoplasm, Nucleus |
| Calculated MW: | 120kDa |
| Observed MW: | 120KDa |
| Synonyms: | EIEE54, HNRNPU-AS1, HNRPU, SAF-A, SAFA, U21.1, hnRNP U |
| Background: | This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | hnRNP U: Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Spliceosome; Nuclear receptor co-regulator; RNA splicing; DNA-binding; RNA-binding Chromosomal Location of Human Ortholog: 1q44 Cellular Component: nucleoplasm; cell surface; membrane; ribonucleoprotein complex; nucleus Molecular Function:protein binding; DNA binding; RNA binding; ATP binding Biological Process: RNA processing; nuclear mRNA splicing, via spliceosome; osteoblast differentiation; RNA splicing; gene expression; circadian regulation of gene expression |
| NCBI Summary: | This gene encodes a member of a family of proteins that bind nucleic acids and function in the formation of ribonucleoprotein complexes in the nucleus with heterogeneous nuclear RNA (hnRNA). The encoded protein has affinity for both RNA and DNA, and binds scaffold-attached region (SAR) DNA. Mutations in this gene have been associated with epileptic encephalopathy, early infantile, 54. A pseudogene of this gene has been identified on chromosome 14. [provided by RefSeq, Jun 2017] |
| UniProt Code: | Q00839 |
| NCBI GenInfo Identifier: | 254763463 |
| NCBI Gene ID: | 3192 |
| NCBI Accession: | Q00839.6 |
| UniProt Related Accession: | Q00839 |
| Molecular Weight: | |
| NCBI Full Name: | Heterogeneous nuclear ribonucleoprotein U |
| NCBI Synonym Full Names: | heterogeneous nuclear ribonucleoprotein U |
| NCBI Official Symbol: | HNRNPU |
| NCBI Official Synonym Symbols: | SAFA; HNRPU; SAF-A; U21.1; pp120; EIEE54; GRIP120; hnRNP U; HNRNPU-AS1 |
| NCBI Protein Information: | heterogeneous nuclear ribonucleoprotein U |
| UniProt Protein Name: | Heterogeneous nuclear ribonucleoprotein U |
| UniProt Synonym Protein Names: | Scaffold attachment factor A; SAF-A; p120; pp120 |
| Protein Family: | Heterogeneous nuclear ribonucleoprotein |
| UniProt Gene Name: | HNRNPU |
| UniProt Entry Name: | HNRPU_HUMAN |
 | Western blot - hnRNP U Rabbit mAb (CAB4257) |
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