Anti-hnRNP Q Antibody (CAB9609)
- SKU:
- CAB9609
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| Antibody Name: | Anti-hnRNP Q Antibody |
| Antibody SKU: | CAB9609 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human hnRNP Q |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Mouse brain, Mouse heart, Rat lung, Rat spleen, Rat thymus |
| Immunogen: | A synthesized peptide derived from human hnRNP Q |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10492 |
| Uniprot: | O60506 |
| Cellular Location: | |
| Calculated MW: | 65-82kDa |
| Observed MW: | 70-85KDa |
| Synonyms: | GRY-RBP, GRYRBP, HNRNPQ, HNRPQ1, NSAP1, PP68, hnRNP-Q |
| Background: | This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011] |
| UniProt Protein Function: | NSAP1: a heterogeneous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. A component of the spliceosome. Five alternatively spliced isoforms have been described. Isoform 1, 2 and 3 are associated with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to ACF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. |
| UniProt Protein Details: | Protein type:RNA splicing; Motility/polarity/chemotaxis; Spliceosome; RNA-binding Chromosomal Location of Human Ortholog: 6q14-q15 Cellular Component: membrane; nucleus; ribonucleoprotein complex Molecular Function:protein binding; RNA binding Biological Process: negative regulation of translation; nuclear mRNA splicing, via spliceosome; osteoblast differentiation; RNA processing; RNA splicing |
| NCBI Summary: | This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011] |
| UniProt Code: | O60506 |
| NCBI GenInfo Identifier: | 92090361 |
| NCBI Gene ID: | 10492 |
| NCBI Accession: | O60506.2 |
| UniProt Secondary Accession: | O60506,Q53H05, Q5TCG2, Q5TCG3, Q8IW78, Q8N599, Q96LC1 Q96LC2, Q9Y583, E1P501, E1P502, |
| UniProt Related Accession: | O60506 |
| Molecular Weight: | 46,328 Da |
| NCBI Full Name: | Heterogeneous nuclear ribonucleoprotein Q |
| NCBI Synonym Full Names: | synaptotagmin binding cytoplasmic RNA interacting protein |
| NCBI Official Symbol: | SYNCRIP |
| NCBI Official Synonym Symbols: | PP68; NSAP1; GRYRBP; HNRNPQ; HNRPQ1; GRY-RBP; hnRNP-Q |
| NCBI Protein Information: | heterogeneous nuclear ribonucleoprotein Q |
| UniProt Protein Name: | Heterogeneous nuclear ribonucleoprotein Q |
| UniProt Synonym Protein Names: | Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; NS1-associated protein 1; Synaptotagmin-binding, cytoplasmic RNA-interacting protein |
| Protein Family: | Heterogeneous nuclear ribonucleoprotein |
| UniProt Gene Name: | SYNCRIP |
| UniProt Entry Name: | HNRPQ_HUMAN |
 | Western blot - hnRNP Q Rabbit mAb (CAB9609) |
Related Products
Anti-hnRNP A1 Antibody (CAB11564)
Anti-hnRNP K Antibody (CAB0772)
Anti-hnRNP E1/PCBP1 Antibody (CAB19276)
Anti-hnRNP C1 + C2 Antibody (CAB8958)
