Anti-hnRNP A1 Antibody (CAB11564)
- SKU:
- CAB11564
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| Antibody Name: | Anti-hnRNP A1 Antibody |
| Antibody SKU: | CAB11564 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human hnRNP A1 |
| Application: | WB IHC IF IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, HepG2, Mouse brain, Rat brain |
| Immunogen: | A synthesized peptide derived from human hnRNP A1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3178 |
| Uniprot: | P09651 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 33kDa |
| Observed MW: | 30KDa/35KDa/40KDa |
 | Western blot - hnRNP A1 Rabbit mAb (CAB11564) |
| Synonyms: | ALS19, ALS20, HNRPA1, HNRPA1L3, IBMPFD3, UP 1, hnRNP A1, hnRNP-A1 |
| Background: | This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20. Multiple alternatively spliced transcript variants have been found. There are numerous pseudogenes of this gene distributed throughout the genome. [provided by RefSeq, Feb 2016] |
| UniProt Protein Function: | hnRNP A1: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication. Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with SEPT6. Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding; RNA splicing; Spliceosome; Nuclear export Chromosomal Location of Human Ortholog: 12q13.1 Cellular Component: cytoplasm; membrane; nucleoplasm; nucleus; ribonucleoprotein complex; spliceosome Molecular Function:protein binding; RNA binding; single-stranded DNA binding; single-stranded RNA binding Biological Process: fibroblast growth factor receptor signaling pathway; gene expression; mRNA processing; negative regulation of telomere maintenance via telomerase; nuclear export; nuclear import; nuclear mRNA splicing, via spliceosome; positive regulation of telomere maintenance via telomerase; RNA export from nucleus Disease: Amyotrophic Lateral Sclerosis 20; Inclusion Body Myopathy With Early-onset Paget Disease With Or Without Frontotemporal Dementia 3 |
| NCBI Summary: | This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20. Multiple alternatively spliced transcript variants have been found. There are numerous pseudogenes of this gene distributed throughout the genome. [provided by RefSeq, Feb 2016] |
| UniProt Code: | P09651 |
| NCBI GenInfo Identifier: | 288558857 |
| NCBI Gene ID: | 3178 |
| NCBI Accession: | P09651.5 |
| UniProt Secondary Accession: | P09651,Q3MIB7, Q6PJZ7, A8K4Z8, |
| UniProt Related Accession: | P09651 |
| Molecular Weight: | 29,386 Da |
| NCBI Full Name: | Heterogeneous nuclear ribonucleoprotein A1 |
| NCBI Synonym Full Names: | heterogeneous nuclear ribonucleoprotein A1 |
| NCBI Official Symbol: | HNRNPA1 |
| NCBI Official Synonym Symbols: | UP 1; ALS19; ALS20; HNRPA1; IBMPFD3; HNRPA1L3; hnRNP A1; hnRNP-A1 |
| NCBI Protein Information: | heterogeneous nuclear ribonucleoprotein A1 |
| UniProt Protein Name: | Heterogeneous nuclear ribonucleoprotein A1 |
| UniProt Synonym Protein Names: | Helix-destabilizing protein; Single-strand RNA-binding protein; hnRNP core protein A1 |
| Protein Family: | Heterogeneous nuclear ribonucleoproteins |
| UniProt Gene Name: | HNRNPA1 |
| UniProt Entry Name: | ROA1_HUMAN |
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