| Background: | HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. |
| UniProt Protein Function: | Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. |
| NCBI Summary: | HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P28067 |
| NCBI GenInfo Identifier: | 133158 |
| NCBI Gene ID: | 3108 |
| NCBI Accession: | P28067.1 |
| UniProt Secondary Accession: | P28067,Q29639, Q29640, |
| UniProt Related Accession: | P28067 |
| Molecular Weight: | 28 |
| NCBI Full Name: | HLA class II histocompatibility antigen, DM alpha chain |
| NCBI Synonym Full Names: | major histocompatibility complex, class II, DM alpha |
| NCBI Official Symbol: | HLA-DMA |
| NCBI Official Synonym Symbols: | DMA; HLADM; RING6; D6S222E |
| NCBI Protein Information: | HLA class II histocompatibility antigen, DM alpha chain |
| UniProt Protein Name: | HLA class II histocompatibility antigen, DM alpha chain |
| UniProt Synonym Protein Names: | MHC class II antigen DMA; Really interesting new gene 6 protein |
| UniProt Gene Name: | HLA-DMA |
