Anti-Histone H2B Antibody (CAB18305)
- SKU:
- CAB18305
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-Histone H2B Antibody |
| Antibody SKU: | CAB18305 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of Human Histone H2B. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | A synthetic peptide of Human Histone H2B. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8349 |
| Uniprot: | Q16778 |
| Cellular Location: | |
| Calculated MW: | 14kDa |
| Observed MW: | Refer to figures |
| Synonyms: | GL105, H2B, H2B.1, H2BFQ, H2BGL105, H2BQ, Histone H2B, HIST2H2BE |
| Background: | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. The protein has antibacterial and antifungal antimicrobial activity. |
| UniProt Protein Function: | H2B2E: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H2B family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 1q21.2 Cellular Component: nucleoplasm; extracellular space; nucleosome; nucleus Molecular Function:DNA binding; protein heterodimerization activity Biological Process: nucleosome assembly; defense response to Gram-positive bacterium; establishment and/or maintenance of chromatin architecture; innate immune response in mucosa; antibacterial humoral response |
| NCBI Summary: | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. The protein has antibacterial and antifungal antimicrobial activity. [provided by RefSeq, Aug 2015] |
| UniProt Code: | Q16778 |
| NCBI GenInfo Identifier: | 7387736 |
| NCBI Gene ID: | 8349 |
| NCBI Accession: | Q16778.3 |
| UniProt Related Accession: | Q16778 |
| Molecular Weight: | 14kDa |
| NCBI Full Name: | Histone H2B type 2-E |
| NCBI Synonym Full Names: | H2B clustered histone 21 |
| NCBI Official Symbol: | H2BC21 |
| NCBI Official Synonym Symbols: | H2B; H2BQ; GL105; H2B.1; H2BFQ; H2BGL105; HIST2H2BE |
| NCBI Protein Information: | histone H2B type 2-E |
| UniProt Protein Name: | Histone H2B type 2-E |
| UniProt Synonym Protein Names: | Histone H2B-GL105; Histone H2B.q; H2B/q |
| Protein Family: | Histone |
| UniProt Gene Name: | HIST2H2BE |
| UniProt Entry Name: | H2B2E_HUMAN |
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