Anti-HIP1R Antibody (CAB12026)
- SKU:
- CAB12026
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-HIP1R Antibody |
| Antibody SKU: | CAB12026 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human HIP1R (NP_003950.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, 293T, HeLa, Mouse brain, Mouse spleen, Mouse liver, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human HIP1R (NP_003950.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KPVV VIPE EAPE DEEP ENLI EIST GPPA GEPV VVAD LFDQ TFGP PNGS VKDD RDLQ IESL KREV EMLR SELE KIKL EAQR YIAQ LKSQ VNAL EGEL EEQR KQKQ KALV DNEQ LRHE LAQL RAAQ LEGE RSQG LREE AERK ASAT EARY NKLK EKHS ELVH VHAE LLRK NADT AKQL TVTQ QSQE EVAR VKEQ LAFQ VEQV KRES ELKL EEKS DQLE KLKR ELEA KAGE LARA QEAL SHTE QSKS ELSS RLDT LSAE KDAL SGAV RQRE ADLL AAQS LVRE TEAA LSRE QQRS SQEQ GELQ G |
| Gene ID: | 9026 |
| Uniprot: | O75146 |
| Cellular Location: | Cytoplasm, Cytoplasmic vesicle, Endomembrane system, clathrin-coated vesicle membrane, perinuclear region |
| Calculated MW: | 70kDa/119kDa |
| Observed MW: | 130kDa |
| Synonyms: | HIP1R, HIP12, HIP3, ILWEQ |
| Background: |
| UniProt Protein Function: | HIP1R: Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. Belongs to the SLA2 family. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 12q24 Cellular Component: cytoskeleton; intracellular membrane-bound organelle; clathrin-coated vesicle; perinuclear region of cytoplasm; cytoplasm; clathrin coated vesicle membrane; coated pit Molecular Function:protein binding, bridging; protein binding; actin binding; phosphoinositide binding Biological Process: receptor-mediated endocytosis; actin cytoskeleton organization and biogenesis |
| UniProt Code: | O75146 |
| NCBI GenInfo Identifier: | 13431563 |
| NCBI Gene ID: | 9026 |
| NCBI Accession: | O75146.2 |
| UniProt Related Accession: | O75146 |
| Molecular Weight: | |
| NCBI Full Name: | Huntingtin-interacting protein 1-related protein |
| NCBI Synonym Full Names: | huntingtin interacting protein 1 related |
| NCBI Official Symbol: | HIP1R |
| NCBI Official Synonym Symbols: | HIP3; HIP12; ILWEQ |
| NCBI Protein Information: | huntingtin-interacting protein 1-related protein |
| UniProt Protein Name: | Huntingtin-interacting protein 1-related protein |
| UniProt Synonym Protein Names: | Huntingtin-interacting protein 12; HIP-12 |
| Protein Family: | Huntingtin-interacting protein 1-related protein |
| UniProt Gene Name: | HIP1R |
| UniProt Entry Name: | HIP1R_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HIP1R antibody (CAB12026) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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