| UniProt Protein Function: | HEYL: Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Belongs to the HEY family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1p34.3 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:AF-1 domain binding; protein binding; protein heterodimerization activity; transcription corepressor activity; transcription factor activity Biological Process: mesenchymal cell development; negative regulation of transcription, DNA-dependent; Notch signaling pathway; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NQ87 |
| NCBI GenInfo Identifier: | 146286205 |
| NCBI Gene ID: | 26508 |
| NCBI Accession: | Q9NQ87.2 |
| UniProt Secondary Accession: | Q9NQ87,Q5TG99, |
| UniProt Related Accession: | Q9NQ87 |
| Molecular Weight: | 35,087 Da |
| NCBI Full Name: | Hairy/enhancer-of-split related with YRPW motif-like protein |
| NCBI Synonym Full Names: | hes related family bHLH transcription factor with YRPW motif-like |
| NCBI Official Symbol: | HEYL |
| NCBI Official Synonym Symbols: | HEY3; HRT3; HESR3; bHLHb33 |
| NCBI Protein Information: | hairy/enhancer-of-split related with YRPW motif-like protein |
| UniProt Protein Name: | Hairy/enhancer-of-split related with YRPW motif-like protein |
| UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 33; bHLHb33; Hairy-related transcription factor 3; HRT-3; hHRT3 |
| Protein Family: | Hairy/enhancer-of-split related with YRPW motif-like protein |
| UniProt Gene Name: | HEYL |
| UniProt Entry Name: | HEYL_HUMAN |
