Anti-HEPACAM Antibody (CAB11589)
- SKU:
- CAB11589
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-HEPACAM Antibody |
| Antibody SKU: | CAB11589 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-245 of human HEPACAM (NP_689935.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, HepG2, MCF7, SH-SY5Y, SGC-7901, Mouse brain, Mouse liver, Rat brain, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-245 of human HEPACAM (NP_689935.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NITS PVRL IHGT VGKS ALLS VQYS STSS DRPV VKWQ LKRD KPVT VVQS IGTE VIGT LRPD YRDR IRLF ENGS LLLS DLQL ADEG TYEV EISI TDDT FTGE KTIN LTVD VPIS RPQV LVAS TTVL ELSE AFTL NCSH ENGT KPSY TWLK DGKP LLND SRML LSPD QKVL TITR VLME DDDL YSCM VENP ISQG RSLP VKIT VYRR SSLY IIL |
| Gene ID: | 220296 |
| Uniprot: | Q14CZ8 |
| Cellular Location: | Cytoplasm, Cytoplasmic side, Membrane, Single-pass type I membrane protein |
| Calculated MW: | 40kDa/46kDa |
| Observed MW: | 70kDa |
| Synonyms: | HEPACAM, GlialCAM, MLC2A, MLC2B |
| Background: | The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. |
| UniProt Code: | Q14CZ8 |
| NCBI GenInfo Identifier: | 121674801 |
| NCBI Gene ID: | 220296 |
| NCBI Accession: | NP_689935.2 |
| UniProt Secondary Accession: | Q14CZ8,Q67IP8, Q6ZWL4, Q8N7I3, Q8ND35, |
| UniProt Related Accession: | Q14CZ8 |
| Molecular Weight: | 46,026 Da |
| NCBI Full Name: | hepatocyte cell adhesion molecule |
| NCBI Synonym Full Names: | hepatic and glial cell adhesion molecule |
| NCBI Official Symbol: | HEPACAM |
| NCBI Official Synonym Symbols: | MLC2A; MLC2B; FLJ25530; GlialCAM |
| NCBI Protein Information: | hepatocyte cell adhesion molecule; protein hepaCAM; OTTHUMP00000231540; cancer susceptibility; glial cell adhesion molecule |
| UniProt Protein Name: | Hepatocyte cell adhesion molecule |
| Protein Family: | HEPACAM family |
| UniProt Gene Name: | HEPACAM |
| UniProt Entry Name: | HECAM_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HEPACAM antibody (CAB11589) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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