Anti-HCAR2 Antibody (CAB15611)
- SKU:
- CAB15611
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Antibody Name: | Anti-HCAR2 Antibody |
Antibody SKU: | CAB15611 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IF |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human HCAR2 (NP_808219.1). |
Application: | WB IF |
Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | HepG2, Rat heart |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human HCAR2 (NP_808219.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | VRIR IFWL LHTS GTQN CEVY RSVD LAFF ITLS FTYM NSML DPVV YYFS SPSF PNFF STLI NRCL QRKM TGEP DNNR STSV ELTG DPNK TRGA PEAL MANS G |
Gene ID: | 338442 |
Uniprot: | Q8TDS4 |
Cellular Location: | |
Calculated MW: | 42kDa |
Observed MW: | 42kDa |
Synonyms: | HCAR2, GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g |
Background: |
UniProt Protein Function: | GPR109A: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5- methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. Belongs to the G-protein coupled receptor 1 family. |
UniProt Protein Details: | Protein type:Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: cell junction; plasma membrane Biological Process: negative regulation of lipid catabolic process; neutrophil apoptosis; positive regulation of neutrophil apoptosis |
UniProt Code: | Q8TDS4 |
NCBI GenInfo Identifier: | 74762622 |
NCBI Gene ID: | 338442 |
NCBI Accession: | Q8TDS4.1 |
UniProt Secondary Accession: | Q8TDS4,A0PJL5, A7LGG3, |
UniProt Related Accession: | Q8TDS4 |
Molecular Weight: | 41,850 Da |
NCBI Full Name: | Hydroxycarboxylic acid receptor 2 |
NCBI Synonym Full Names: | hydroxycarboxylic acid receptor 2 |
NCBI Official Symbol: | HCAR2 |
NCBI Official Synonym Symbols: | HCA2; HM74a; HM74b; PUMAG; NIACR1; Puma-g; GPR109A |
NCBI Protein Information: | hydroxycarboxylic acid receptor 2 |
UniProt Protein Name: | Hydroxycarboxylic acid receptor 2 |
UniProt Synonym Protein Names: | G-protein coupled receptor 109A; G-protein coupled receptor HM74A; Niacin receptor 1; Nicotinic acid receptor |
Protein Family: | Hydroxycarboxylic acid receptor |
UniProt Gene Name: | HCAR2 |
UniProt Entry Name: | HCAR2_HUMAN |