Anti-H6PD Antibody (CAB6440)
- SKU:
- CAB6440
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-H6PD Antibody |
| Antibody SKU: | CAB6440 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human H6PD (NP_004276.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human H6PD (NP_004276.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QELQ GHVS IILL GATG DLAK KYLW QGLF QLYL DEAG RGHS FSFH GAAL TAPK QGQE LMAK ALES LSCP KDMA PSHC AEHK DQFL QLSQ YRQL KTAE DYQA LNKD IEAQ LQHA GLRE AGRI FYFS VPPF AYED IARN INSS CRPG PGAW LRVV LEKP FGHD HFSA QQLA TELG TFFQ EEEM Y |
| Gene ID: | 9563 |
| Uniprot: | O95479 |
| Cellular Location: | Endoplasmic reticulum lumen |
| Calculated MW: | 88kDa |
| Observed MW: | 89kDa |
| Synonyms: | H6PD, CORTRD1, G6PDH, GDH |
| Background: | There are 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific for glucose-6-phosphate. Both forms are present in most tissues, but H form is not found in red cells. |
| UniProt Protein Function: | H6PD: Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates. Defects in H6PD are a cause of cortisone reductase deficiency (CRD). In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS). |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 3.1.1.31; EC 1.1.1.47; Carbohydrate Metabolism - pentose phosphate pathway; Hydrolase Chromosomal Location of Human Ortholog: 1p36 Disease: Cortisone Reductase Deficiency 1 |
| NCBI Summary: | There are 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific for glucose-6-phosphate. Both forms are present in most tissues, but H form is not found in red cells. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95479 |
| NCBI GenInfo Identifier: | 108884809 |
| NCBI Gene ID: | 9563 |
| NCBI Accession: | O95479.2 |
| UniProt Secondary Accession: | O95479,Q4TT33, Q66I35, Q68DT3, |
| UniProt Related Accession: | O95479 |
| Molecular Weight: | 88,893 Da |
| NCBI Full Name: | GDH/6PGL endoplasmic bifunctional protein |
| NCBI Synonym Full Names: | hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase |
| NCBI Official Symbol: | H6PD |
| NCBI Official Synonym Symbols: | GDH; G6PDH; CORTRD1 |
| NCBI Protein Information: | GDH/6PGL endoplasmic bifunctional protein |
| UniProt Protein Name: | GDH/6PGL endoplasmic bifunctional protein |
| UniProt Synonym Protein Names: | Glucose 1-dehydrogenase (EC:1.1.1.47)Alternative name(s):Hexose-6-phosphate dehydrogenase |
| Protein Family: | GDH/6PGL endoplasmic bifunctional protein |
| UniProt Gene Name: | H6PD |
| UniProt Entry Name: | G6PE_HUMAN |
 | Western blot analysis of extracts of various cell lines, using H6PD Antibody (CAB6440) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using H6PD antibody (CAB6440) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using H6PD antibody (CAB6440). Blue: DAPI for nuclear staining. |
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