Anti-GZMK Antibody (CAB10219)
- SKU:
- CAB10219
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-GZMK Antibody |
| Antibody SKU: | CAB10219 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-264 of human GZMK (NP_002095.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-264 of human GZMK (NP_002095.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IIGG KEVS PHSR PFMA SIQY GGHH VCGG VLID PQWV LTAA HCQY RFTK GQSP TVVL GAHS LSKN EASK QTLE IKKF IPFS RVTS DPQS NDIM LVKL QTAA KLNK HVKM LHIR SKTS LRSG TKCK VTGW GATD PDSL RPSD TLRE VTVT VLSR KLCN SQSY YNGD PFIT KDMV CAGD AKGQ KDSC KGDS GGPL ICKG VFHA IVSG GHEC GVAT KPGI YTLL TKKY QTWI KSNL VPPH TN |
| Gene ID: | 3003 |
| Uniprot: | P49863 |
| Cellular Location: | Cytoplasmic granule, Secreted |
| Calculated MW: | 28kDa |
| Observed MW: | 29kDa |
| Synonyms: | GZMK, TRYP2 |
| Background: | This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. |
| NCBI Summary: | This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49863 |
| NCBI GenInfo Identifier: | 1708035 |
| NCBI Gene ID: | 3003 |
| NCBI Accession: | P49863.1 |
| UniProt Secondary Accession: | P49863,B2R563, |
| UniProt Related Accession: | P49863 |
| Molecular Weight: | |
| NCBI Full Name: | Granzyme K |
| NCBI Synonym Full Names: | granzyme K |
| NCBI Official Symbol: | GZMK |
| NCBI Official Synonym Symbols: | TRYP2 |
| NCBI Protein Information: | granzyme K |
| UniProt Protein Name: | Granzyme K |
| UniProt Synonym Protein Names: | Fragmentin-3; Granzyme-3; NK-tryptase-2; NK-Tryp-2 |
| Protein Family: | Granzyme |
| UniProt Gene Name: | GZMK |
 | Western blot analysis of extracts of various cell lines, using GZMK antibody (CAB10219) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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