Anti-GYPB Antibody (CAB7682)
- SKU:
- CAB7682
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-GYPB Antibody |
| Antibody SKU: | CAB7682 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-91 of human GYPB (NP_002091.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Human serum |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-91 of human GYPB (NP_002091.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MYGK IIFV LLLS EIVS ISAL STTE VAMH TSTS SSVT KSYI SSQT NGET GQLV HRFT VPAP VVII LIIL CVMA GIIG TILL ISYT IRRL IKA |
| Gene ID: | 2994 |
| Uniprot: | P06028 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 6kDa/9kDa |
| Observed MW: | 25kDa |
| Synonyms: | GYPB, CD235b, GPB, GYP, MNS, PAS-3, SS |
| Background: | Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | GYPB: This protein is a minor sialoglycoprotein in erythrocyte membranes. Belongs to the glycophorin-A family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 4q31.21 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:protein binding Disease: Malaria, Susceptibility To |
| NCBI Summary: | Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] |
| UniProt Code: | P06028 |
| NCBI GenInfo Identifier: | 380865467 |
| NCBI Gene ID: | 2994 |
| NCBI Accession: | P06028.3 |
| UniProt Secondary Accession: | P06028,Q0VAF4, Q58HE9, Q58HF0, Q58HF1, Q9UCH7, B8Q174 E2QBW7, |
| UniProt Related Accession: | P06028 |
| Molecular Weight: | 6,352 Da |
| NCBI Full Name: | Glycophorin-B |
| NCBI Synonym Full Names: | glycophorin B (MNS blood group) |
| NCBI Official Symbol: | GYPB |
| NCBI Official Synonym Symbols: | SS; GPB; GYP; MNS; PAS-3; CD235b |
| NCBI Protein Information: | glycophorin-B |
| UniProt Protein Name: | Glycophorin-B |
| UniProt Synonym Protein Names: | PAS-3; SS-active sialoglycoprotein; Sialoglycoprotein delta; CD_antigen: CD235b |
| Protein Family: | Glycophorin |
| UniProt Gene Name: | GYPB |
| UniProt Entry Name: | GLPB_HUMAN |
 | Western blot analysis of extracts of Human serum, using GYPB Rabbit pAb (CAB7682) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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