Anti-GUCY2F Antibody (CAB14242)
- SKU:
- CAB14242
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-GUCY2F Antibody |
| Antibody SKU: | CAB14242 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-460 of human GUCY2F (NP_001513.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse eye |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-460 of human GUCY2F (NP_001513.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HSAL IGGE TQMH LLEC AHDL KMTD GTYV FVPY DALL YSLP YKHT PYRV LRNN PKLR EAYD AVLT ITVE SQEK TFYQ AFTE AAAR GEIP EKLE FDQV SPLF GTIY NSIY FIAQ AMNN AMKE NGQA GAAS LVQH SRNM QFHG FNQL MRTD SNGN GISE YVIL DTNL KEWE LHST YTVD MEME LLRF GGTP IHFP GGRP PRAD AKCW FAEG KIC |
| Gene ID: | 2986 |
| Uniprot: | P51841 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 124kDa |
| Observed MW: | 125kDa |
| Synonyms: | GUCY2F, CYGF, GC-F, GUC2DL, GUC2F, RETGC-2, ROS-GC2 |
| Background: | The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. |
| UniProt Protein Function: | GUCY2F: Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. |
| UniProt Protein Details: | Protein type:Protein kinase, dual-specificity (receptor); Receptor, misc.; Kinase, protein; EC 4.6.1.2; Nucleotide Metabolism - purine; Membrane protein, integral; Protein kinase, RGC; Guanylyl cyclase; Lyase; RGC group; RGC family Chromosomal Location of Human Ortholog: Xq22 Cellular Component: guanylate cyclase complex, soluble; integral to plasma membrane; nuclear outer membrane Molecular Function:adenylate cyclase activity; guanylate cyclase activity; receptor activity Biological Process: receptor guanylyl cyclase signaling pathway; regulation of rhodopsin mediated signaling; visual perception |
| NCBI Summary: | The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008] |
| UniProt Code: | P51841 |
| NCBI GenInfo Identifier: | 311033391 |
| NCBI Gene ID: | 2986 |
| NCBI Accession: | P51841.2 |
| UniProt Secondary Accession: | P51841,Q9UJF1, |
| UniProt Related Accession: | P51841 |
| Molecular Weight: | 124,850 Da |
| NCBI Full Name: | Retinal guanylyl cyclase 2 |
| NCBI Synonym Full Names: | guanylate cyclase 2F, retinal |
| NCBI Official Symbol: | GUCY2F |
| NCBI Official Synonym Symbols: | CYGF; GC-F; GUC2F; GUC2DL; RETGC-2; ROS-GC2 |
| NCBI Protein Information: | retinal guanylyl cyclase 2 |
| UniProt Protein Name: | Retinal guanylyl cyclase 2 |
| UniProt Synonym Protein Names: | Guanylate cyclase 2F, retinal; Guanylate cyclase F; GC-F; Rod outer segment membrane guanylate cyclase 2; ROS-GC2 |
| Protein Family: | Retinal guanylyl cyclase |
| UniProt Gene Name: | GUCY2F |
| UniProt Entry Name: | GUC2F_HUMAN |
 | Western blot analysis of extracts of mouse eye, using GUCY2F antibody (CAB14242) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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