Anti-GUCY1B3 Antibody (CAB15276)

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SKU:
CAB15276
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
Frequently bought together:

Description

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Antibody Name:Anti-GUCY1B3 Antibody
Antibody SKU:CAB15276
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human GUCY1B3 (NP_000848.1).
Application:WB IHC
Recommended Dilution:WB 1:200 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat lung, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human GUCY1B3 (NP_000848.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MYGF VNHA LELL VIRN YGPE VWED IKKE AQLD EEGQ FLVR IIYD DSKT YDLV AAAS KVLN LNAG EILQ MFGK MFFV FCQE SGYD TILR VLGS NVRE FLQN LDAL HDHL ATIY PGMR APSF RCTD AEKG KGLI LHYY SERE GLQD IVIG IIKT VAQQ IHGT EIDM KVIQ QRNE ECDH TQFL IEEK ESKE EDFY EDLD RFEE NGTQ ESRI SPYT FCKA FPFH IIFD RDLV VTQC GNAI YRVL PQLQ PGNC SL
Gene ID:2983
Uniprot:Q02153
Cellular Location:Cytoplasm
Calculated MW:66kDa/68kDa/70kDa
Observed MW:70kDa
Synonyms:GUCY1B3, GC-S-beta-1, GC-SB3, GUC1B3, GUCB3, GUCSB3, GUCY1B1
Background:This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:GUCY1B3: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Heterodimer of an alpha and a beta chain. 2 isoforms of the human protein are produced by alternative splicing
UniProt Protein Details:

Protein type:Receptor, misc.; Guanylyl cyclase; Lyase; Nucleotide Metabolism - purine; EC 4.6.1.2

Chromosomal Location of Human Ortholog: 4q31.3-q33

Cellular Component: guanylate cyclase complex, soluble; intracellular membrane-bound organelle; cytoplasm

Molecular Function:guanylate cyclase activity; GTP binding; protein heterodimerization activity; metal ion binding; heme binding; Hsp90 protein binding; receptor activity

Biological Process: cGMP biosynthetic process; blood circulation; blood coagulation; nitric oxide mediated signal transduction

NCBI Summary:This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
UniProt Code:Q02153
NCBI GenInfo Identifier:399328
NCBI Gene ID:2983
NCBI Accession:Q02153.1
UniProt Secondary Accession:Q02153,Q86WY5, B7Z426,
UniProt Related Accession:Q02153
Molecular Weight:619
NCBI Full Name:Guanylate cyclase soluble subunit beta-1
NCBI Synonym Full Names:guanylate cyclase 1, soluble, beta 3
NCBI Official Symbol:GUCY1B3  
NCBI Official Synonym Symbols:GUCB3; GC-SB3; GUC1B3; GUCSB3; GUCY1B1; GC-S-beta-1  
NCBI Protein Information:guanylate cyclase soluble subunit beta-1; GCS-beta-1; GCS-beta-3; soluble guanylate cyclase small subunit; guanylate cyclase soluble subunit beta-3
UniProt Protein Name:Guanylate cyclase soluble subunit beta-1
UniProt Synonym Protein Names:Guanylate cyclase soluble subunit beta-3; GCS-beta-3; Soluble guanylate cyclase small subunit
Protein Family:Guanylate cyclase soluble
UniProt Gene Name:GUCY1B3  
UniProt Entry Name:GCYB1_HUMAN
Anti-GUCY1B3 Antibody (CAB15276)Western blot analysis of extracts of various cell lines, using GUCY1B3 antibody (CAB15276) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30S.

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