Anti-Guanylate kinase Antibody (CAB8656)

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SKU:
CAB8656
Product type:
Antibody
Application:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-Guanylate kinase Antibody
Antibody SKU:CAB8656
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-197 of human GUK1 (NP_000849.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:1000
Reactivity:Human
Positive Samples:LO2, SKOV3, BT-474, Jurkat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-197 of human GUK1 (NP_000849.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSGP RPVV LSGP SGAG KSTL LKRL LQEH SGIF GFSV SHTT RNPR PGEE NGKD YYFV TREV MQRD IAAG DFIE HAEF SGNL YGTS KVAV QAVQ AMNR ICVL DVDL QGVR NIKA TDLR PIYI SVQP PSLH VLEQ RLRQ RNTE TEES LVKR LAAA QADM ESSK EPGL FDVV IIND SLDQ AYAE LKEA LSEE IKKA QRTG A
Gene ID:2987
Uniprot:Q16774
Cellular Location:
Calculated MW:21kDa/23kDa/26kDa
Observed MW:21kDa
Synonyms:GUK1, GMK
Background:The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:GUK1: Essential for recycling GMP and indirectly, cGMP. Belongs to the guanylate kinase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Kinase, other; Nucleotide Metabolism - purine; EC 2.7.4.8

Chromosomal Location of Human Ortholog: 1q32-q41

Cellular Component: cytosol

Molecular Function:ATP binding; guanylate kinase activity

Biological Process: ATP metabolic process; dATP metabolic process; dGDP biosynthetic process; dGMP metabolic process; drug metabolic process; GDP biosynthetic process; GDP-mannose metabolic process; GMP metabolic process; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; nucleotide phosphorylation; purine nucleotide metabolic process

NCBI Summary:The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
UniProt Code:Q16774
NCBI GenInfo Identifier:4504221
NCBI Gene ID:2987
NCBI Accession:NP_000849.1
UniProt Secondary Accession:Q16774,B1ANH1,
UniProt Related Accession:Q16774
Molecular Weight:37.6 kDa
NCBI Full Name:guanylate kinase isoform b
NCBI Synonym Full Names:guanylate kinase 1
NCBI Official Symbol:GUK1  
NCBI Official Synonym Symbols:GMK  
NCBI Protein Information:guanylate kinase
UniProt Protein Name:Guanylate kinase
UniProt Synonym Protein Names:GMP kinase
Protein Family:Guanylate kinase
UniProt Gene Name:GUK1  
UniProt Entry Name:KGUA_HUMAN
Anti-Guanylate kinase Polyclonal Antibody (CAB8656)Western blot analysis of extracts of various cell lines, using GUK1 antibody (CAB8656) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.

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