Anti-GTSE1 Antibody (CAB13903)
- SKU:
- CAB13903
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-GTSE1 Antibody |
| Antibody SKU: | CAB13903 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-290 of human GTSE1 (NP_057510.4). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-87MG, HeLa, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-290 of human GTSE1 (NP_057510.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LLAD EKFD FDLS LSSS SANE DDEV FFGP FGHK ERCI AASL ELNN PVPE QPPL PTSE SPFA WSPL AGEK FVEV YKEA HLLA LHIE SSSR NQAA QAAK PEDP RSQG VERF IQES KLKI NLFE KEKE MKKS PTSL KRET YYLS DSPL LGPP VGEP RLLA SSPA LPSS GAQA RLTR APGP PHSA HALP RESC TAHA ASQA ATQR KPGT KLLL PRAA SVRG RSIP GAAE KPKK EIPA SPSR TKIP AEKE SHRD VLPD KPAP GAVN V |
| Gene ID: | 51512 |
| Uniprot: | Q9NYZ3 |
| Cellular Location: | Cytoplasm, cytoskeleton |
| Calculated MW: | 76kDa |
| Observed MW: | 77kDa |
| Synonyms: | GTSE1, B99 |
| Background: | The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. |
| UniProt Protein Function: | GTSE1: May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression. |
| UniProt Protein Details: | Protein type:Apoptosis; Cell cycle regulation Chromosomal Location of Human Ortholog: 22q13.2-q13.3 Cellular Component: membrane; cytoplasmic microtubule Molecular Function:protein binding Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; microtubule-based process |
| NCBI Summary: | The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NYZ3 |
| NCBI GenInfo Identifier: | 317373439 |
| NCBI Gene ID: | 51512 |
| NCBI Accession: | Q9NYZ3.3 |
| UniProt Related Accession: | Q9NYZ3 |
| Molecular Weight: | 77kDa |
| NCBI Full Name: | G2 and S phase-expressed protein 1 |
| NCBI Synonym Full Names: | G2 and S-phase expressed 1 |
| NCBI Official Symbol: | GTSE1 |
| NCBI Official Synonym Symbols: | B99 |
| NCBI Protein Information: | G2 and S phase-expressed protein 1 |
| UniProt Protein Name: | G2 and S phase-expressed protein 1 |
| UniProt Synonym Protein Names: | Protein B99 homolog |
| Protein Family: | G2 and S phase-expressed protein |
| UniProt Gene Name: | GTSE1 |
| UniProt Entry Name: | GTSE1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GTSE1 antibody (CAB13903) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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