Anti-GSTZ1 Antibody (CAB6129)
- SKU:
- CAB6129
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-GSTZ1 Antibody |
| Antibody SKU: | CAB6129 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-216 of human GSTZ1 (NP_665877.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse kidney, Rat thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-216 of human GSTZ1 (NP_665877.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MQAG KPIL YSYF RSSC SWRV RIAL ALKG IDYE TVPI NLIK DGGQ QFSK DFQA LNPM KQVP TLKI DGIT IHQS LAII EYLE EMRP TPRL LPQD PKKR ASVR MISD LIAG GIQP LQNL SVLK QVGE EMQL TWAQ NAIT CGFN ALEQ ILQS TAGI YCVG DEVT MADL CLVP QVAN AERF KVDL TPYP TISS INKR LLVL EAFQ VSHP CRQP DTPT ELRA |
| Gene ID: | 2954 |
| Uniprot: | O43708 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 17kDa/19kDa/24kDa |
| Observed MW: | 24KDa |
| Synonyms: | GSTZ1, GSTZ1-1, MAAI, MAI |
| Background: | This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme catalyzes the conversion of maleylacetoacetate to fumarylacetoacatate, which is one of the steps in the phenylalanine/tyrosine degradation pathway. Deficiency of a similar gene in mouse causes oxidative stress. Several transcript variants of this gene encode multiple protein isoforms. |
| UniProt Protein Function: | GSTZ1: Bifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4- nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T- butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. Belongs to the GST superfamily. Zeta family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Xenobiotic Metabolism - metabolism by cytochrome P450; EC 5.2.1.2; Isomerase; Transferase; EC 2.5.1.18; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - tyrosine; Mitochondrial; Oxidoreductase; Other Amino Acids Metabolism - glutathione Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: mitochondrion; cytosol Molecular Function:protein binding; protein homodimerization activity; glutathione transferase activity; maleylacetoacetate isomerase activity; glutathione peroxidase activity Biological Process: L-phenylalanine catabolic process; glutathione metabolic process; tyrosine catabolic process; xenobiotic metabolic process |
| NCBI Summary: | This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43708 |
| NCBI GenInfo Identifier: | 269849671 |
| NCBI Gene ID: | 2954 |
| NCBI Accession: | O43708.3 |
| UniProt Secondary Accession: | O43708,O15308, O75430, Q6IB17, Q7Z610, Q9BV63, A6NED0 A6NNB8, A8MWD7, B2RCK3, |
| UniProt Related Accession: | O43708 |
| Molecular Weight: | 216 |
| NCBI Full Name: | Maleylacetoacetate isomerase |
| NCBI Synonym Full Names: | glutathione S-transferase zeta 1 |
| NCBI Official Symbol: | GSTZ1 |
| NCBI Official Synonym Symbols: | MAI; MAAI; GSTZ1-1 |
| NCBI Protein Information: | maleylacetoacetate isomerase; maleylacetone isomerase; glutathione S-aryltransferase; glutathione S-alkyltransferase; glutathione transferase zeta 1; glutathione S-aralkyltransferase; S-(hydroxyalkyl)glutathione lyase |
| UniProt Protein Name: | Maleylacetoacetate isomerase |
| UniProt Synonym Protein Names: | GSTZ1-1; Glutathione S-transferase zeta 1 (EC:2.5.1.18) |
| Protein Family: | Glutathione S-transferase |
| UniProt Gene Name: | GSTZ1 |
| UniProt Entry Name: | MAAI_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GSTZ1 antibody (CAB6129) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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