Anti-GSTO1 Antibody (CAB15354)

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SKU:
CAB15354
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-GSTO1 Antibody
Antibody SKU:CAB15354
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-241 of human GSTO1 (NP_004823.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:LO2, BxPC-3, HT-29, HeLa, Mouse heart, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-241 of human GSTO1 (NP_004823.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSGE SARS LGKG SAPP GPVP EGSI RIYS MRFC PFAE RTRL VLKA KGIR HEVI NINL KNKP EWFF KKNP FGLV PVLE NSQG QLIY ESAI TCEY LDEA YPGK KLLP DDPY EKAC QKMI LELF SKVP SLVG SFIR SQNK EDYA GLKE EFRK EFTK LEEV LTNK KTTF FGGN SISM IDYL IWPW FERL EAMK LNEC VDHT PKLK LWMA AMKE DPTV SALL TSEK DWQG FLEL YLQN SPEA CDYG L
Gene ID:9446
Uniprot:P78417
Cellular Location:Cytoplasm, cytosol
Calculated MW:23kDa/24kDa/27kDa
Observed MW:27kDa
Synonyms:GSTO1, GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R, GSTO1-1
Background:The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:GSTO1: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Belongs to the GST superfamily. Omega family.
UniProt Protein Details:

Protein type:EC 1.8.5.1; Transferase; EC 1.20.4.2; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Xenobiotic Metabolism - drug metabolism - cytochrome P450

Chromosomal Location of Human Ortholog: 10q25.1

Cellular Component: cytoplasm; cytosol

Molecular Function:glutathione dehydrogenase (ascorbate) activity; glutathione transferase activity; methylarsonate reductase activity; oxidoreductase activity; protein binding

Biological Process: glutathione metabolic process; L-ascorbic acid metabolic process; methylation; positive regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion; xenobiotic catabolic process

NCBI Summary:The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
UniProt Code:P78417
NCBI GenInfo Identifier:6016173
NCBI Gene ID:9446
NCBI Accession:P78417.2
UniProt Secondary Accession:P78417,Q5TA03, Q7Z3T2, D3DRA3, F5H7H0,
UniProt Related Accession:P78417
Molecular Weight:24,796 Da
NCBI Full Name:Glutathione S-transferase omega-1
NCBI Synonym Full Names:glutathione S-transferase omega 1
NCBI Official Symbol:GSTO1  
NCBI Official Synonym Symbols:P28; SPG-R; GSTO 1-1; GSTTLp28; HEL-S-21  
NCBI Protein Information:glutathione S-transferase omega-1
UniProt Protein Name:Glutathione S-transferase omega-1
UniProt Synonym Protein Names:Glutathione S-transferase omega 1-1; GSTO 1-1; Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1
Protein Family:Glutathione S-transferase
UniProt Gene Name:GSTO1  
UniProt Entry Name:GSTO1_HUMAN
Anti-GSTO1 Antibody (CAB15354)Western blot analysis of extracts of various cell lines, using GSTO1 antibody (CAB15354) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

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