Anti-GSTM2 항체 (CAB13496)

Antibody Name:	Anti-GSTM2 Antibody
Antibody SKU:	CAB13496
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC IF
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-218 of human GSTM2 (NP_000839.1).

Application:	WB IHC IF
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:	Human, Mouse
Positive Samples:	Mouse testis

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-218 of human GSTM2 (NP_000839.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MPMT LGYW NIRG LAHS IRLL LEYT DSSY EEKK YTMG DAPD YDRS QWLN EKFK LGLD FPNL PYLI DGTH KITQ SNAI LRYI ARKH NLCG ESEK EQIR EDIL ENQF MDSR MQLA KLCY DPDF EKLK PEYL QALP EMLK LYSQ FLGK QPWF LGDK ITFV DFIA YDVL ERNQ VFEP SCLD AFPN LKDF ISRF EGLE KISA YMKS SRFL PRPV FTKM AVWG NK
Gene ID:	2946
Uniprot:	P28161
Cellular Location:	Cytoplasm
Calculated MW:	22kDa/25kDa
Observed MW:	27kDa

Synonyms:

GSTM2, GST4, GSTM, GSTM2-2, GTHMUS

Background:

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.

UniProt Protein Function:	GSTM2: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Mu family.
UniProt Protein Details:	Protein type:Transferase; EC 2.5.1.18; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1p13.3 Cellular Component: sarcoplasmic reticulum; cytoplasm; cytosol Molecular Function:protein homodimerization activity; enzyme binding; glutathione transferase activity; glutathione binding; receptor binding Biological Process: regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion; glutathione metabolic process; nitrobenzene metabolic process; xenobiotic metabolic process; xenobiotic catabolic process
NCBI Summary:	Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. [provided by RefSeq, Jul 2008]
UniProt Code:	P28161
NCBI GenInfo Identifier:	232204
NCBI Gene ID:	2946
NCBI Accession:	P28161.2
UniProt Secondary Accession:	P28161,Q2M318, Q5TZY5, Q8WWE1, B4DRY4, E9PEM9,
UniProt Related Accession:	P28161
Molecular Weight:	218
NCBI Full Name:	Glutathione S-transferase Mu 2
NCBI Synonym Full Names:	glutathione S-transferase mu 2 (muscle)
NCBI Official Symbol:	GSTM2
NCBI Official Synonym Symbols:	GST4; GSTM; GTHMUS; GSTM2-2
NCBI Protein Information:	glutathione S-transferase Mu 2; GST, muscle; GST class-mu 2; glutathione S-transferase 4; glutathione S-transferase M1; glutathione S-aryltransferase M2; glutathione S-alkyltransferase M2; glutathione S-aralkyltransferase M2; S-(hydroxyalkyl)glutathione lyase M2; glutathione S-transferase M2 (muscle)
UniProt Protein Name:	Glutathione S-transferase Mu 2
UniProt Synonym Protein Names:	GST class-mu 2; GSTM2-2
Protein Family:	Glutathione S-transferase
UniProt Gene Name:	GSTM2
UniProt Entry Name:	GSTM2_HUMAN

	Western blot analysis of extracts of mouse testis, using GSTM2 antibody (CAB13496) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
	Immunohistochemistry of paraffin-embedded human colon using GSTM2 Antibody (CAB13496) at dilution of 1:100 (40x lens).
	Immunofluorescence analysis of A549 cells using GSTM2 antibody (CAB13496). Blue: DAPI for nuclear staining.

ELISA Kits

Human GSTM2 / Glutathione S Transferase Mu 2, Muscle ELISA Kit

Human GSTu2/GSTm2 (Glutathione S Transferase Mu 2, Muscle) CLIA Kit (HUES01140)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)