Anti-GSTA1 Antibody (CAB18266)
- SKU:
- CAB18266
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-GSTA1 Antibody |
| Antibody SKU: | CAB18266 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-222 of human GSTA1 (NP_665683.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, Mouse kidney, Mouse stomach, Rat liver, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-222 of human GSTA1 (NP_665683.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2938 |
| Uniprot: | P08263 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 25kDa |
| Observed MW: | 24kDa |
 | Western blot - GSTA1 Rabbit pAb (CAB18266) |
| Synonyms: | GSTA1, GST-epsilon, GST2, GSTA1-1, GTH1 |
| Background: | This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | GSTA1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Alpha family. |
| UniProt Protein Details: | Protein type:Xenobiotic Metabolism - metabolism by cytochrome P450; Other Amino Acids Metabolism - glutathione; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 2.5.1.18; Transferase Chromosomal Location of Human Ortholog: 6p12.1 Cellular Component: cytosol Molecular Function:glutathione transferase activity Biological Process: glutathione metabolic process; epithelial cell differentiation; metabolic process; xenobiotic metabolic process |
| NCBI Summary: | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08263 |
| NCBI GenInfo Identifier: | 121730 |
| NCBI Gene ID: | 2938 |
| NCBI Accession: | P08263.3 |
| UniProt Secondary Accession: | P08263,Q14750, Q5GHF8, Q5SZC1, |
| UniProt Related Accession: | P08263 |
| Molecular Weight: | 222 |
| NCBI Full Name: | Glutathione S-transferase A1 |
| NCBI Synonym Full Names: | glutathione S-transferase alpha 1 |
| NCBI Official Symbol: | GSTA1 |
| NCBI Official Synonym Symbols: | GST2; GTH1; GSTA1-1 |
| NCBI Protein Information: | glutathione S-transferase A1; GST-epsilon; GST HA subunit 1; GST, class alpha, 1; GST class-alpha member 1; glutathione S-transferase 2; glutathione S-aryltransferase A1; glutathione S-alkyltransferase A1; S-(hydroxyalkyl)glutathione lyase A1; glutathione S-transferase Ha subunit 1 |
| UniProt Protein Name: | Glutathione S-transferase A1 |
| UniProt Synonym Protein Names: | GST HA subunit 1; GST class-alpha member 1; GST-epsilon; GSTA1-1; GTH1Glutathione S-transferase A1, N-terminally processed |
| Protein Family: | Glutathione S-transferase |
| UniProt Gene Name: | GSTA1 |
| UniProt Entry Name: | GSTA1_HUMAN |
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