Anti-GRPEL2 Antibody (CAB8339)

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SKU:
CAB8339
Product type:
Antibody
Application:
WB
Application:
IHC
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-GRPEL2 Antibody
Antibody SKU:CAB8339
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 33-225 of human GRPEL2 (NP_689620.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:U-251MG, LO2, K-562, MCF7, Mouse liver, Mouse kidney, Mouse brain, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 33-225 of human GRPEL2 (NP_689620.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:STAT QRTA GEDC RSED PPDE LGPP LAER ALRV KAVK LEKE VQDL TVRY QRAI ADCE NIRR RTQR CVED AKIF GIQS FCKD LVEV ADIL EKTT ECIS EESE PEDQ KLTL EKVF RGLL LLEA KLKS VFAK HGLE KLTP IGDK YDPH EHEL ICHV PAGV GVQP GTVA LVRQ DGYK LHGR TIRL ARVE VAVE SQRR L
Gene ID:134266
Uniprot:Q8TAA5
Cellular Location:Mitochondrion matrix
Calculated MW:14kDa/25kDa
Observed MW:20kDa
Synonyms:GRPEL2, Mt-GrpE#2, GrpE like 2
Background:
UniProt Protein Function:GRPEL2: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70. Belongs to the GrpE family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial inner membrane

Molecular Function:protein homodimerization activity; adenyl-nucleotide exchange factor activity; chaperone binding; unfolded protein binding

Biological Process: cellular protein metabolic process; protein folding; regulation of catalytic activity; protein targeting to mitochondrion

UniProt Code:Q8TAA5
NCBI GenInfo Identifier:22256760
NCBI Gene ID:134266
NCBI Accession:Q8TAA5.1
UniProt Secondary Accession:Q8TAA5,Q49AJ6, B4DFA6,
UniProt Related Accession:Q8TAA5
Molecular Weight:14,277 Da
NCBI Full Name:GrpE protein homolog 2, mitochondrial
NCBI Synonym Full Names:GrpE-like 2, mitochondrial (E. coli)
NCBI Official Symbol:GRPEL2  
NCBI Official Synonym Symbols:Mt-GrpE#2  
NCBI Protein Information:grpE protein homolog 2, mitochondrial
UniProt Protein Name:GrpE protein homolog 2, mitochondrial
UniProt Synonym Protein Names:Mt-GrpE#2
Protein Family:GrpE protein
UniProt Gene Name:GRPEL2  
UniProt Entry Name:GRPE2_HUMAN
Anti-GRPEL2 Polyclonal Antibody (CAB8339)Western blot analysis of extracts of various cell lines, using GRPEL2 antibody (CAB8339) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-GRPEL2 Polyclonal Antibody (CAB8339)Immunohistochemistry of paraffin-embedded rat kidney using GRPEL2 Rabbit pAb (CAB8339) at dilution of 1:200 (40x lens).
Anti-GRPEL2 Polyclonal Antibody (CAB8339)Immunohistochemistry of paraffin-embedded human colon carcinoma using GRPEL2 Rabbit pAb (CAB8339) at dilution of 1:200 (40x lens).
Anti-GRPEL2 Polyclonal Antibody (CAB8339)Immunohistochemistry of paraffin-embedded mouse kidney using GRPEL2 Rabbit pAb (CAB8339) at dilution of 1:200 (40x lens).

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