Anti-GRO alpha Antibody (CAB5802)
- SKU:
- CAB5802
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| Antibody Name: | Anti-GRO alpha Antibody |
| Antibody SKU: | CAB5802 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-107 of human GRO alpha (NP_001502.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | DU145, Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-107 of human GRO alpha (NP_001502.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MARA ALSA APSN PRLL RVAL LLLL LVAA GRRA AGAS VATE LRCQ CLQT LQGI HPKN IQSV NVKS PGPH CAQT EVIA TLKN GRKA CLNP ASPI VKKI IEKM LNSD KSN |
| Gene ID: | 2919 |
| Uniprot: | P09341 |
| Cellular Location: | Secreted |
| Calculated MW: | 11kDa |
| Observed MW: | 11kDa |
| Synonyms: | CXCL1, FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1, GRO alpha |
| Background: | This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. |
| UniProt Protein Function: | CXCL1: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. Belongs to the intercrine alpha (chemokine CxC) family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 4q21 Cellular Component: extracellular space; extracellular region Molecular Function:growth factor activity; chemokine activity; CXCR chemokine receptor binding; enzyme activator activity; receptor binding Biological Process: positive regulation of catalytic activity; G-protein coupled receptor protein signaling pathway; cell proliferation; nervous system development; negative regulation of cell proliferation; immune response; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; inflammatory response; actin cytoskeleton organization and biogenesis; chemotaxis; signal transduction |
| NCBI Summary: | This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P09341 |
| NCBI GenInfo Identifier: | 121622 |
| NCBI Gene ID: | 2919 |
| NCBI Accession: | P09341.1 |
| UniProt Secondary Accession: | P09341,Q9UCR7, |
| UniProt Related Accession: | P09341 |
| Molecular Weight: | |
| NCBI Full Name: | Growth-regulated alpha protein |
| NCBI Synonym Full Names: | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
| NCBI Official Symbol: | CXCL1 |
| NCBI Official Synonym Symbols: | FSP; GRO1; GROa; MGSA; NAP-3; SCYB1; MGSA-a |
| NCBI Protein Information: | growth-regulated alpha protein; MGSA alpha; GRO-alpha(1-73); C-X-C motif chemokine 1; fibroblast secretory protein; neutrophil-activating protein 3; melanoma growth stimulatory activity alpha; GRO1 oncogene (melanoma growth-stimulating activity); GRO1 oncogene (melanoma growth stimulating activity, alpha) |
| UniProt Protein Name: | Growth-regulated alpha protein |
| UniProt Synonym Protein Names: | C-X-C motif chemokine 1; GRO-alpha(1-73); Melanoma growth stimulatory activity; MGSA; Neutrophil-activating protein 3; NAP-3 |
| Protein Family: | Growth-regulated alpha protein |
| UniProt Gene Name: | CXCL1 |
| UniProt Entry Name: | GROA_HUMAN |
 | Western blot analysis of extracts of DU145 cells, using GRO alpha antibody (CAB5802) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Western blot analysis of extracts of Jurkat cells, using GRO alpha antibody (CAB5802) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
Related Products
Anti-PKC alpha Antibody (CAB11107)
Anti-Alpha Internexin Antibody (CAB3596)
Anti-PGC1 alpha Antibody (CAB11971)
