Anti-GPSM1 Antibody (CAB8713)
- SKU:
- CAB8713
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-GPSM1 Antibody |
| Antibody SKU: | CAB8713 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 158-457 of human GPSM1 (NP_056412.5). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-87MG, HT-29, MCF7, Jurkat, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 158-457 of human GPSM1 (NP_056412.5). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AKGK QLSW NAAN ATQD PGHL PPDV RETL CKAS EFYE RNLS LVKE LGDR AAQG RAYG NLGN THYL LGNF TEAT TFHK ERLA IAKE FGDK AAER RAYS NLGN AHVF LGRF DVAA EYYK KTLQ LSRQ LRDQ AVEA QACY SLGN TYTL LQDY ERAA EYHL RHLL IAQE LADR VGEG RACW SLGN AYVS MGRP AQAL TFAK KHLQ ISQE IGDR HGEL TARM NVAQ LQLV LGRL TSPA ASEK PDLA GYEA QGEF QGCG GVLL PTGT DRIR SCGG VGSR PGQH GGGG SRQK MAPT SQFF LASG TAQA |
| Gene ID: | 26086 |
| Uniprot: | Q86YR5 |
| Cellular Location: | Cell membrane, Cytoplasm, Cytoplasmic side, Endoplasmic reticulum membrane, Golgi apparatus membrane, Peripheral membrane protein, cytosol |
| Calculated MW: | 18kDa/49kDa/72kDa/74kDa |
| Observed MW: | 72kDa |
| Synonyms: | GPSM1, AGS3 |
| Background: | G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | GPSM1: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. Belongs to the GPSM family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GEFs; GEFs, misc. Chromosomal Location of Human Ortholog: 9q34.3 Cellular Component: Golgi membrane; nucleoplasm; Golgi apparatus; endoplasmic reticulum membrane; plasma membrane; cytosol Molecular Function:GDP-dissociation inhibitor activity Biological Process: nervous system development; regulation of catalytic activity; cell differentiation; regulation of G-protein coupled receptor protein signaling pathway |
| NCBI Summary: | G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q86YR5 |
| NCBI GenInfo Identifier: | 294862435 |
| NCBI Gene ID: | 26086 |
| NCBI Accession: | Q86YR5.2 |
| UniProt Secondary Accession: | Q86YR5,Q86SR5, Q969T1, Q9UFS8, A9Z1X4, B1B0W3, |
| UniProt Related Accession: | Q86YR5 |
| Molecular Weight: | 72,136 Da |
| NCBI Full Name: | G-protein-signaling modulator 1 |
| NCBI Synonym Full Names: | G-protein signaling modulator 1 |
| NCBI Official Symbol: | GPSM1 |
| NCBI Official Synonym Symbols: | AGS3 |
| NCBI Protein Information: | G-protein-signaling modulator 1; activator of G-protein signaling 3; G-protein signalling modulator 1 (AGS3-like, C. elegans) |
| UniProt Protein Name: | G-protein-signaling modulator 1 |
| UniProt Synonym Protein Names: | Activator of G-protein signaling 3 |
| Protein Family: | G-protein-signaling modulator |
| UniProt Gene Name: | GPSM1 |
| UniProt Entry Name: | GPSM1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GPSM1 antibody (CAB8713) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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