Anti-GPR55 Antibody (CAB12890)
- SKU:
- CAB12890
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-GPR55 Antibody |
| Antibody SKU: | CAB12890 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-319 of human GPR55 (NP_005674.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-319 of human GPR55 (NP_005674.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GRRD HTQD WVQQ KACI YSIA ASLA VFVV SFLP VHLG FFLQ FLVR NSFI VECR AKQS ISFF LQLS MCFS NVNC CLDV FCYY FVIK EFRM NIRA HRPS RVQL VLQD TTIS RG |
| Gene ID: | 9290 |
| Uniprot: | Q9Y2T6 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 36kDa |
| Observed MW: | 37kDa |
| Synonyms: | GPR55, LPIR1 |
| Background: | This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. |
| UniProt Protein Function: | GPR55: May be involved in hyperalgesia associated with inflammatory and neuropathic pain. Receptor for L- alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 2q37.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:cannabinoid receptor activity; G-protein coupled receptor activity Biological Process: bone resorption; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor protein signaling pathway; negative regulation of osteoclast differentiation; phospholipase C activation; positive regulation of Rho protein signal transduction |
| NCBI Summary: | This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q9Y2T6 |
| NCBI GenInfo Identifier: | 71159390 |
| NCBI Gene ID: | 9290 |
| NCBI Accession: | Q9Y2T6.2 |
| UniProt Secondary Accession: | Q9Y2T6,Q8N580, |
| UniProt Related Accession: | Q9Y2T6 |
| Molecular Weight: | Calculated MW: 36kDaObserved MW: 37kDa |
| NCBI Full Name: | G-protein coupled receptor 55 |
| NCBI Synonym Full Names: | G protein-coupled receptor 55 |
| NCBI Official Symbol: | GPR55 |
| NCBI Official Synonym Symbols: | LPIR1 |
| NCBI Protein Information: | G-protein coupled receptor 55 |
| UniProt Protein Name: | G-protein coupled receptor 55 |
| Protein Family: | G-protein coupled receptor |
| UniProt Gene Name: | GPR55 |
 | Western blot analysis of extracts of various cell lines, using GPR55 antibody (CAB12890) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of rat bone marrow cells using GPR55 antibody (CAB12890) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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