Anti-GPIHBP1 Antibody (CAB13240)
- SKU:
- CAB13240
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-GPIHBP1 Antibody |
| Antibody SKU: | CAB13240 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-151 of human GPIHBP1 (NP_835466.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG, LO2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-151 of human GPIHBP1 (NP_835466.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ETNR LPGG RSRV LLRC YTCK SLPR DERC NLTQ NCSH GQTC TTLI AHGN TESG LLTT HSTW CTDS CQPI TKTV EGTQ VTMT CCQS SLCN VPPW QSSR VQDP TG |
| Gene ID: | 338328 |
| Uniprot: | Q8IV16 |
| Cellular Location: | Apical cell membrane, Basolateral cell membrane, Cell membrane, Extracellular side, GPI-anchor, Lipid-anchor, Peripheral membrane protein |
| Calculated MW: | 19kDa |
| Observed MW: | 20kDa |
| Synonyms: | GPIHBP1, GPI-HBP1, HYPL1D |
| Background: | This gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | GPIHBP1: Plays a key role in the lipolytic processing of chylomicrons. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 8q24.3 Cellular Component: anchored to external side of plasma membrane; apical plasma membrane; basolateral plasma membrane; external side of plasma membrane Molecular Function:protein transmembrane transporter activity Biological Process: cholesterol homeostasis; intracellular protein transport; positive regulation of lipoprotein lipase activity; protein import; protein stabilization; transcytosis Disease: Hyperlipoproteinemia, Type Id |
| NCBI Summary: | This gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014] |
| UniProt Code: | Q8IV16 |
| NCBI GenInfo Identifier: | 684179339 |
| NCBI Gene ID: | 338328 |
| NCBI Accession: | NP_001288701.1 |
| UniProt Secondary Accession: | Q8IV16,Q6P3T2, Q86W15, |
| UniProt Related Accession: | Q8IV16 |
| Molecular Weight: | 19,806 Da |
| NCBI Full Name: | glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 isoform 2 |
| NCBI Synonym Full Names: | glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 |
| NCBI Official Symbol: | GPIHBP1 |
| NCBI Official Synonym Symbols: | HYPL1D; GPI-HBP1 |
| NCBI Protein Information: | glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 |
| UniProt Protein Name: | Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 |
| UniProt Synonym Protein Names: | High density lipoprotein-binding protein 1 |
| Protein Family: | Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein |
| UniProt Gene Name: | GPIHBP1 |
 | Western blot analysis of extracts of various cell lines, using GPIHBP1 antibody (CAB13240) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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