Anti-GP9 Antibody (CAB5374)
- SKU:
- CAB5374
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| Antibody Name: | Anti-GP9 Antibody |
| Antibody SKU: | CAB5374 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-147 of human GP9 (NP_000165.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:20 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-87MG, Mouse lung, Mouse spleen, Mouse liver, Mouse skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-147 of human GP9 (NP_000165.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TKDC PSPC TCRA LETM GLWV DCRG HGLT ALPA LPAR TRHL LLAN NSLQ SVPP GAFD HLPQ LQTL DVTQ NPWH CDCS LTYL RLWL EDRT PEAL LQVR CASP SLAA HGPL GRLT GYQL GSCG WQLQ ASWV RPG |
| Gene ID: | 2815 |
| Uniprot: | P14770 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 19kDa |
| Observed MW: | 19kDa |
| Synonyms: | GP9, CD42a, GPIX |
| Background: | This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. |
| UniProt Protein Function: | GPIX: The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib. Defects in GP9 are a cause of Bernard-Soulier syndrome (BSS); also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 3q21.3 Cellular Component: integral to plasma membrane; plasma membrane Biological Process: platelet activation; blood coagulation; cell adhesion; blood coagulation, intrinsic pathway Disease: Bernard-soulier Syndrome |
| NCBI Summary: | This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. [provided by RefSeq, Oct 2008] |
| UniProt Code: | P14770 |
| NCBI GenInfo Identifier: | 2822110 |
| NCBI Gene ID: | 2815 |
| NCBI Accession: | P14770.3 |
| UniProt Secondary Accession: | P14770,Q14445, Q8N1D1, Q92525, |
| UniProt Related Accession: | P14770 |
| Molecular Weight: | 177 |
| NCBI Full Name: | Platelet glycoprotein IX |
| NCBI Synonym Full Names: | glycoprotein IX (platelet) |
| NCBI Official Symbol: | GP9 |
| NCBI Official Synonym Symbols: | GPIX; CD42a |
| NCBI Protein Information: | platelet glycoprotein IX; glycoprotein 9 |
| UniProt Protein Name: | Platelet glycoprotein IX |
| UniProt Synonym Protein Names: | Glycoprotein 9; CD_antigen: CD42a |
| Protein Family: | Platelet glycoprotein |
| UniProt Gene Name: | GP9 |
| UniProt Entry Name: | GPIX_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GP9 antibody (CAB5374) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of A-549 cells using GP9 antibody (CAB5374). Blue: DAPI for nuclear staining. |
Related Products
Anti-NOX2/gp91phox Antibody (CAB12430)
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
