Anti-GOT1 Antibody (CAB11363)
- SKU:
- CAB11363
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-GOT1 Antibody |
| Antibody SKU: | CAB11363 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human GOT1 |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, A-549, U-87MG, Mouse liver, Mouse brain, Mouse heart, Rat liver, Rat brain, Rat kidney |
| Immunogen: | A synthesized peptide derived from human GOT1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2805 |
| Uniprot: | P17174 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 46kDa |
| Observed MW: | 41KDa |
 | Western blot - GOT1 Rabbit mAb (CAB11363) |
| Synonyms: | AST1, ASTQTL1, GIG18, cAspAT, cCAT |
| Background: | Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | GOT1: Plays a key role in amino acid metabolism. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - arginine and proline; Transferase; EC 2.6.1.1; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - cysteine and methionine; EC 2.6.1.3; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - alanine, aspartate and glutamate Chromosomal Location of Human Ortholog: 10q24.1-q25.1 Cellular Component: lysosome; cytoplasm; nerve terminal; cytosol; nucleus Molecular Function:cysteine transaminase activity; carboxylic acid binding; phosphatidylserine decarboxylase activity; aspartate transaminase activity; pyridoxal phosphate binding Biological Process: glutamate metabolic process; oxaloacetate metabolic process; glutamate catabolic process to aspartate; response to glucocorticoid stimulus; aspartate biosynthetic process; glucose metabolic process; pathogenesis; 2-oxoglutarate metabolic process; gluconeogenesis; methionine salvage; cellular response to insulin stimulus; sulfur amino acid metabolic process; glycerol biosynthetic process; fatty acid homeostasis; carbohydrate metabolic process; aspartate catabolic process; aspartate metabolic process; amino acid biosynthetic process; glutamate catabolic process to 2-oxoglutarate; polyamine metabolic process Disease: Aspartate Aminotransferase, Serum Level Of, Quantitative Trait Locus 1 |
| NCBI Summary: | Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P17174 |
| NCBI GenInfo Identifier: | 5902703 |
| NCBI Gene ID: | 2805 |
| NCBI Accession: | P17174.3 |
| UniProt Secondary Accession: | P17174,Q5VW80, B2R6R7, B7Z7E9, |
| UniProt Related Accession: | P17174 |
| Molecular Weight: | Calculated MW: 44kDa/46kDaObserved MW: 46kDa |
| NCBI Full Name: | Aspartate aminotransferase, cytoplasmic |
| NCBI Synonym Full Names: | glutamic-oxaloacetic transaminase 1, soluble |
| NCBI Official Symbol: | GOT1 |
| NCBI Official Synonym Symbols: | cCAT; GIG18; cAspAT; ASTQTL1 |
| NCBI Protein Information: | aspartate aminotransferase, cytoplasmic; transaminase A; aspartate transaminase 1; aspartate aminotransferase 1; growth-inhibiting protein 18; cysteine transaminase, cytoplasmic; glutamate oxaloacetate transaminase 1; cysteine aminotransferase, cytoplasmic |
| UniProt Protein Name: | Aspartate aminotransferase, cytoplasmic |
| UniProt Synonym Protein Names: | Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase A |
| Protein Family: | Protein transport protein |
| UniProt Gene Name: | GOT1 |
| UniProt Entry Name: | AATC_HUMAN |
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