Anti-GOSR2 Antibody (CAB4321)
- SKU:
- CAB4321
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-GOSR2 Antibody |
| Antibody SKU: | CAB4321 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human GOSR2 (NP_004278.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A-549, HT-29, MCF7, HT-1080, HepG2, K-562 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human GOSR2 (NP_004278.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDPL FQQT HKQV HEIQ SCMG RLET ADKQ SVHI VENE IQAS IDQI FSRL ERLE ILSS KEPP NKRQ NARL RVDQ LKYD VQHL QTAL RNFQ HRRH AREQ QERQ REEL LSRT FTTN DSDT TIPM DESL QFNS SLQK VHNG MDDL ILDG HNIL DGLR TQRL TLKG TQKK ILDI ANML GLSN TVMR LIEK RAFQ DK |
| Gene ID: | 9570 |
| Uniprot: | O14653 |
| Cellular Location: | Golgi apparatus, Golgi apparatus membrane, Single-pass type IV membrane protein, cis-Golgi network membrane |
| Calculated MW: | 22kDa/24kDa |
| Observed MW: | 24kDa |
| Synonyms: | GOSR2, Bos1, EPM6, GS27 |
| Background: | This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. |
| UniProt Protein Function: | GOSR2: Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network. Defects in GOSR2 are the cause of progressive myoclonic epilepsy type 6 (EPM6). A neurologic disorder characterized by onset of ataxia in the first years of life, followed by action myoclonus and seizures later in childhood, and loss of independent ambulation in the second decade. Cognition is not usually affected, although mild memory difficulties may occur in the third decade. Belongs to the GOSR2 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum; Membrane protein, integral Chromosomal Location of Human Ortholog: 17q21 Cellular Component: Golgi membrane; SNARE complex; Golgi apparatus; endoplasmic reticulum membrane; Golgi stack; membrane; late endosome membrane; integral to membrane Molecular Function:SNAP receptor activity; SNARE binding; transporter activity Biological Process: intra-Golgi vesicle-mediated transport; ER to Golgi vesicle-mediated transport; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; unfolded protein response; Golgi to vacuole transport; vesicle fusion with Golgi apparatus; protein targeting to vacuole; retrograde transport, endosome to Golgi Disease: Epilepsy, Progressive Myoclonic 6 |
| NCBI Summary: | This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14653 |
| NCBI GenInfo Identifier: | 22654242 |
| NCBI Gene ID: | 9570 |
| NCBI Accession: | O14653.2 |
| UniProt Secondary Accession: | O14653,Q8N4B8, Q96DA5, Q9BZZ4, D3DXJ5, D3DXJ6, |
| UniProt Related Accession: | O14653 |
| Molecular Weight: | 212 |
| NCBI Full Name: | Golgi SNAP receptor complex member 2 |
| NCBI Synonym Full Names: | golgi SNAP receptor complex member 2 |
| NCBI Official Symbol: | GOSR2 |
| NCBI Official Synonym Symbols: | Bos1; EPM6; GS27 |
| NCBI Protein Information: | Golgi SNAP receptor complex member 2; membrin; 27 kDa Golgi SNARE protein |
| UniProt Protein Name: | Golgi SNAP receptor complex member 2 |
| UniProt Synonym Protein Names: | 27 kDa Golgi SNARE protein; Membrin |
| Protein Family: | Golgi SNAP receptor complex |
| UniProt Gene Name: | GOSR2 |
| UniProt Entry Name: | GOSR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GOSR2 antibody (CAB4321) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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