Anti-GNAO1 Antibody (CAB2510)
- SKU:
- CAB2510
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-GNAO1 Antibody |
| Antibody SKU: | CAB2510 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-180 of human GNAO1 (NP_066268.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse brain, Mouse spinal cord |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-180 of human GNAO1 (NP_066268.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GFSG EDVK QYKP VVYS NTIQ SLAA IVRA MDTL GIEY GDKE RKAD AKMV CDVV SRME DTEP FSAE LLSA MMRL WGDS GIQE CFNR SREY QLND SAKY YLDS LDRI GAAD YQPT EQDI LRTR V |
| Gene ID: | 2775 |
| Uniprot: | P09471 |
| Cellular Location: | Cell membrane, Lipid-anchor, Membrane |
| Calculated MW: | 40kDa |
| Observed MW: | 39kDa |
| Synonyms: | GNAO1, EIEE17, G-ALPHA-o, GNAO, HLA-DQB1, NEDIM |
| Background: | The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | G-alpha(o): Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. Interacts with RGS14. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Belongs to the G-alpha family. G(i/o/t/z) subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:G protein, heterotrimeric alpha G((i/o/t/z)); G protein; G protein, heterotrimeric Chromosomal Location of Human Ortholog: 16q13 Cellular Component: neuron projection; plasma membrane; heterotrimeric G-protein complex Molecular Function:corticotropin-releasing hormone receptor 1 binding; GTPase activity; signal transducer activity; GTP binding; mu-type opioid receptor binding; metal ion binding; G-protein beta/gamma-subunit binding; GTPase activating protein binding; metabotropic serotonin receptor binding Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; response to drug; negative regulation of calcium ion transport; response to hydrogen peroxide; muscle contraction; metabolic process; response to cytokine stimulus; forebrain development; dopamine receptor signaling pathway; response to morphine; locomotory behavior; neurite development; regulation of heart contraction; positive regulation of GTPase activity; aging Disease: Epileptic Encephalopathy, Early Infantile, 17 |
| NCBI Summary: | The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015] |
| UniProt Code: | P09471 |
| NCBI GenInfo Identifier: | 232133 |
| NCBI Gene ID: | 2775 |
| NCBI Accession: | P09471.4 |
| UniProt Related Accession: | P09471 |
| Molecular Weight: | |
| NCBI Full Name: | Guanine nucleotide-binding protein G(o) subunit alpha |
| NCBI Synonym Full Names: | G protein subunit alpha o1 |
| NCBI Official Symbol: | GNAO1 |
| NCBI Official Synonym Symbols: | GNAO; NEDIM; EIEE17; HLA-DQB1; G-ALPHA-o |
| NCBI Protein Information: | guanine nucleotide-binding protein G(o) subunit alpha |
| UniProt Protein Name: | Guanine nucleotide-binding protein G(o) subunit alpha |
| UniProt Gene Name: | GNAO1 |
| UniProt Entry Name: | GNAO_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GNAO1 antibody (CAB2510) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using GNAO1 Antibody (CAB2510) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human esophagus using GNAO1 Antibody (CAB2510) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human esophageal cancer using GNAO1 Antibody (CAB2510) at dilution of 1:100 (40x lens). |
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