Anti-GNAI3 Antibody (CAB13307)[KO Validated]
- SKU:
- CAB13307
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Antibody Name: | Anti-GNAI3 Antibody [KO Validated] |
Antibody SKU: | CAB13307 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IF IP |
Reactivity: | Human, Mouse |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-354 of human GNAI3 (NP_006487.1). |
Application: | WB IF IP |
Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 IP 1:50 - 1:100 |
Reactivity: | Human, Mouse |
Positive Samples: | LO2, MCF-7, HL-60, HT-1080 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-354 of human GNAI3 (NP_006487.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | MGCT LSAE DKAA VERS KMID RNLR EDGE KAAK EVKL LLLG AGES GKST IVKQ MKII HEDG YSED ECKQ YKVV VYSN TIQS IIAI IRAM GRLK IDFG EAAR ADDA RQLF VLAG SAEE GVMT PELA GVIK RLWR DGGV QACF SRSR EYQL NDSA SYYL NDLD RISQ SNYI PTQQ DVLR TRVK TTGI VETH FTFK DLYF KMFD VGGQ RSER KKWI HCFE GVTA IIFC VALS DYDL VLAE DEEM NRMH ESMK LFDS ICNN KWFT ETSI ILFL NKKD LFEE KIKR SPLT ICYP EYTG SNTY EEAA AYIQ CQFE DLNR RKDT KEIY THFT CATD TKNV QFVF DAVT DVII KNNL KECG LY |
Gene ID: | 2773 |
Uniprot: | P08754 |
Cellular Location: | Cell membrane, Cytoplasm, Lipid-anchor, Membrane, centrosome, cytoskeleton, microtubule organizing center |
Calculated MW: | 40kDa |
Observed MW: | 45kDa |
Synonyms: | GNAI3, 87U6, ARCND1 |
Background: | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. |
UniProt Protein Function: | G-alpha i3: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. Defects in GNAI3 are the cause of auriculocondylar syndrome 1 (ARCND1). ARCND1 is an autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. Belongs to the G-alpha family. G(i/o/t/z) subfamily. |
UniProt Protein Details: | Protein type:G protein; G protein, heterotrimeric alpha G((i/o/t/z)); G protein, heterotrimeric Chromosomal Location of Human Ortholog: 1p13 Cellular Component: centrosome; cytoplasm; heterotrimeric G-protein complex; lysosomal membrane; membrane; midbody; plasma membrane Molecular Function:G-protein beta/gamma-subunit binding; G-protein-coupled receptor binding; GDP binding; GTP binding; GTPase activity; protein binding; signal transducer activity Biological Process: cell division; dopamine receptor signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; GTP metabolic process; negative regulation of adenylate cyclase activity; protein folding Disease: Auriculocondylar Syndrome 1 |
NCBI Summary: | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012] |
UniProt Code: | P08754 |
NCBI GenInfo Identifier: | 120996 |
NCBI Gene ID: | 2773 |
NCBI Accession: | P08754.3 |
UniProt Secondary Accession: | P08754,P17539, Q5TZX1, |
UniProt Related Accession: | P08754 |
Molecular Weight: | 40,532 Da |
NCBI Full Name: | Guanine nucleotide-binding protein G(k) subunit alpha |
NCBI Synonym Full Names: | G protein subunit alpha i3 |
NCBI Official Symbol: | GNAI3 |
NCBI Official Synonym Symbols: | 87U6; ARCND1 |
NCBI Protein Information: | guanine nucleotide-binding protein G(k) subunit alpha |
UniProt Protein Name: | Guanine nucleotide-binding protein G(k) subunit alpha |
UniProt Synonym Protein Names: | G(i) alpha-3 |
UniProt Gene Name: | GNAI3 |
UniProt Entry Name: | GNAI3_HUMAN |