Anti-GLP1 Antibody (CAB4981)

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SKU:
CAB4981
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
GLP-1
GLP1
GLP2
GRPP
Frequently bought together:

Description

Product Name:GLP1 Rabbit mAb
Product Code:CAB4981
Size:20uL, 50uL, 100uL
Synonyms:GLP-1, GLP1, GLP2, GRPP
Applications:IHC, IF
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human GLP1
Applications:IHC, IF
Recommended Dilutions:IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Mouse, Rat
Immunogen:A synthesized peptide derived from human GLP1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2641
Uniprot:P01275
Cellular Location:Secreted
Calculated MW:11kDa
UniProt Protein Function:GCG: Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. GLP-1 and GLP-2 are induced in response to nutrient ingestion. Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain. Belongs to the glucagon family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted; Hormone

Chromosomal Location of Human Ortholog: 2q36-q37

Cellular Component: extracellular space; endoplasmic reticulum lumen; extracellular region; plasma membrane

Molecular Function:identical protein binding; protein binding; hormone activity; glucagon receptor binding; receptor binding

Biological Process: positive regulation of protein binding; positive regulation of histone H3-K4 methylation; signal transduction; positive regulation of peptidyl-serine phosphorylation; G-protein signaling, coupled to cAMP nucleotide second messenger; response to starvation; G-protein coupled receptor protein signaling pathway; cell proliferation; cellular protein metabolic process; positive regulation of protein kinase activity; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; feeding behavior; regulation of insulin secretion; negative regulation of apoptosis

NCBI Summary:The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008]
UniProt Code:P01275
NCBI GenInfo Identifier:125987831
NCBI Gene ID:2641
NCBI Accession:P01275.3
UniProt Secondary Accession:P01275,Q53TP6, A6NN65,
UniProt Related Accession:P01275
Molecular Weight:20,909 Da
NCBI Full Name:Glucagon
NCBI Synonym Full Names:glucagon
NCBI Official Symbol:GCG  
NCBI Official Synonym Symbols:GLP1; GLP2; GRPP  
NCBI Protein Information:glucagon; preproglucagon; glucagon-like peptide 1; glucagon-like peptide 2; glicentin-related polypeptide
UniProt Protein Name:Glucagon
UniProt Synonym Protein Names:Incretin hormone
Protein Family:Glucagon
UniProt Gene Name:GCG  
UniProt Entry Name:GLUC_HUMAN

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