Anti-GITR Ligand/TNFSF18 Antibody (CAB7028)
- SKU:
- CAB7028
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| Antibody Name: | Anti-GITR Ligand/TNFSF18 Antibody |
| Antibody SKU: | CAB7028 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 72-199 of human GITR Ligand/TNFSF18 (NP_005083.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW620, SKOV3, Mouse skeletal muscle, Rat skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 72-199 of human GITR Ligand/TNFSF18 (NP_005083.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QLET AKEP CMAK FGPL PSKW QMAS SEPP CVNK VSDW KLEI LQNG LYLI YGQV APNA NYND VAPF EVRL YKNK DMIQ TLTN KSKI QNVG GTYE LHVG DTID LIFN SEHQ VLKN NTYW GIIL LANP QFIS |
| Gene ID: | 8995 |
| Uniprot: | Q9UNG2 |
| Cellular Location: | Cell membrane, Single-pass type II membrane protein |
| Calculated MW: | 22kDa |
| Observed MW: | 46kDa |
| Synonyms: | TNFSF18, AITRL, GITRL, TL6, TNLG2A, hGITRL |
| Background: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. |
| UniProt Protein Function: | TNFSF18: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Belongs to the tumor necrosis factor family. |
| UniProt Protein Details: | Protein type:Apoptosis; Membrane protein, integral; Cytokine Chromosomal Location of Human Ortholog: 1q23 Cellular Component: extracellular space; cell surface; integral to membrane; plasma membrane Molecular Function:cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding; receptor binding Biological Process: cell-cell signaling; tumor necrosis factor-mediated signaling pathway; T cell proliferation during immune response; regulation of T cell proliferation; signal transduction; negative regulation of apoptosis; activation of NF-kappaB transcription factor |
| NCBI Summary: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UNG2 |
| NCBI GenInfo Identifier: | 325511353 |
| NCBI Gene ID: | 8995 |
| NCBI Accession: | Q9UNG2.2 |
| UniProt Secondary Accession: | Q9UNG2,O95852, Q6ISV1, A9IQG8, |
| UniProt Related Accession: | Q9UNG2 |
| Molecular Weight: | 22,724 Da |
| NCBI Full Name: | Tumor necrosis factor ligand superfamily member 18 |
| NCBI Synonym Full Names: | tumor necrosis factor (ligand) superfamily, member 18 |
| NCBI Official Symbol: | TNFSF18 |
| NCBI Official Synonym Symbols: | TL6; AITRL; GITRL; hGITRL |
| NCBI Protein Information: | tumor necrosis factor ligand superfamily member 18; AITR ligand; GITR ligand; activation-inducible TNF-related ligand; glucocorticoid-induced TNF-related ligand; glucocorticoid-induced TNFR-related protein ligand |
| UniProt Protein Name: | Tumor necrosis factor ligand superfamily member 18 |
| UniProt Synonym Protein Names: | Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL |
| UniProt Gene Name: | TNFSF18 |
| UniProt Entry Name: | TNF18_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GITR Ligand/TNFSF18 antibody (CAB7028) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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