Anti-GHSR Antibody (CAB1840)
- SKU:
- CAB1840
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GHSR Antibody |
| Antibody SKU: | CAB1840 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GHSR (NP_940799.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GHSR (NP_940799.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MWNA TPSE EPGF NLTL ADLD WDAS PGND SLGD ELLQ LFPA PLLA GVTA TCVA LFVV GIAG NLLT MLVV SRFR ELRT TTNL YLSS MAFS DLLI FLCM PLDL |
| Gene ID: | 2693 |
| Uniprot: | Q92847 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 32kDa/41kDa |
| Observed MW: | 41kDa |
| Synonyms: | GHSR, GHDP |
| Background: | This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature. |
| UniProt Protein Function: | GHSR: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). Defects in GHSR may be a cause of idiopathic short stature autosomal (ISSA). Short stature is defined by a subnormal rate of growth. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1 Chromosomal Location of Human Ortholog: 3q26.31 Cellular Component: neuron projection; cell surface; plasma membrane; integral to membrane; lipid raft Molecular Function:G-protein coupled receptor activity; growth hormone secretagogue receptor activity; peptide hormone binding; growth hormone-releasing hormone receptor activity Biological Process: response to food; positive regulation of insulin-like growth factor receptor signaling pathway; hormone-mediated signaling; response to hormone stimulus; negative regulation of interleukin-6 biosynthetic process; adult feeding behavior; positive regulation of multicellular organism growth; decidualization; negative regulation of interleukin-1 beta production; negative regulation of insulin secretion; growth hormone secretion; G-protein coupled receptor protein signaling pathway; positive regulation of fatty acid metabolic process; regulation of synaptogenesis; cellular response to insulin stimulus; negative regulation of inflammatory response; actin polymerization and/or depolymerization; positive regulation of appetite; regulation of hindgut contraction; negative regulation of tumor necrosis factor biosynthetic process Disease: Short Stature, Idiopathic, Autosomal |
| NCBI Summary: | This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010] |
| UniProt Code: | Q92847 |
| NCBI GenInfo Identifier: | 2494998 |
| NCBI Gene ID: | 2693 |
| NCBI Accession: | Q92847.1 |
| UniProt Secondary Accession: | Q92847,Q14D12, Q6ISR8, Q92848, Q96RJ7, |
| UniProt Related Accession: | Q92847 |
| Molecular Weight: | 289 |
| NCBI Full Name: | Growth hormone secretagogue receptor type 1 |
| NCBI Synonym Full Names: | growth hormone secretagogue receptor |
| NCBI Official Symbol: | GHSR |
| NCBI Protein Information: | growth hormone secretagogue receptor type 1; GHRP; GHS-R; ghrelin receptor; GH-releasing peptide receptor |
| UniProt Protein Name: | Growth hormone secretagogue receptor type 1 |
| UniProt Synonym Protein Names: | GH-releasing peptide receptor; GHRP; Ghrelin receptor |
| Protein Family: | Growth hormone secretagogue receptor |
| UniProt Gene Name: | GHSR |
| UniProt Entry Name: | GHSR_HUMAN |
 | Western blot analysis of extracts of rat brain, using GHSR antibody (CAB1840) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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