Anti-GHRHR 항체 (CAB8421)

Antibody Name:	Anti-GHRHR Antibody
Antibody SKU:	CAB8421
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human GHRHR (NP_000814.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	U-251MG, Mouse brain, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human GHRHR (NP_000814.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MDRR MWGA HVFC VLSP LPTV LGHM HPEC DFIT QLRE DESA CLQA AEEM PNTT LGCP ATWD GLLC WPTA GSGE WVTL PCPD FFSH FSSE SGAV KRDC TITG WSEP FPPY PVAC PVPL ELLA EEES YFST VK
Gene ID:	2692
Uniprot:	Q02643
Cellular Location:	Cell membrane, Multi-pass membrane protein
Calculated MW:	47kDa
Observed MW:	55kDa

Synonyms:	GHRHR, GHRFR, GRFR, IGHD1B
Background:	This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature.

UniProt Protein Function:	GHRHR: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. Defects in GHRHR are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Belongs to the G-protein coupled receptor 2 family.
UniProt Protein Details:	Protein type:Membrane protein, integral; Membrane protein, multi-pass; Cell development/differentiation; Receptor, GPCR; GPCR, family 2 Chromosomal Location of Human Ortholog: 7p14 Cellular Component: nuclear outer membrane; nuclear matrix; cell surface; cytoplasm; integral to membrane; plasma membrane; nuclear inner membrane; secretory granule Molecular Function:G-protein coupled receptor activity; protein binding; peptide hormone binding; growth factor binding; growth hormone-releasing hormone receptor activity Biological Process: lactation; positive regulation of insulin-like growth factor receptor signaling pathway; response to glucocorticoid stimulus; cell maturation; adenylate cyclase activation; regulation of protein metabolic process; positive regulation of multicellular organism growth; determination of adult life span; reproductive process in a multicellular organism; G-protein signaling, adenylate cyclase activating pathway; response to insulin stimulus; positive regulation of growth hormone secretion; water homeostasis; growth hormone secretion; cAMP-mediated signaling; cellular response to insulin stimulus; response to estrogen stimulus; positive regulation of cell proliferation; positive regulation of cAMP biosynthetic process; somatotropin secreting cell development; hormone metabolic process; regulation of steroid hormone receptor signaling pathway Disease: Isolated Growth Hormone Deficiency, Type Ib
NCBI Summary:	This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]
UniProt Code:	Q02643
NCBI GenInfo Identifier:	3041685
NCBI Gene ID:	2692
NCBI Accession:	Q02643.2
UniProt Secondary Accession:	Q02643,Q99863,
UniProt Related Accession:	Q02643
Molecular Weight:	47,402 Da
NCBI Full Name:	Growth hormone-releasing hormone receptor
NCBI Synonym Full Names:	growth hormone releasing hormone receptor
NCBI Official Symbol:	GHRHR
NCBI Official Synonym Symbols:	GRFR; GHRFR; IGHD1B
NCBI Protein Information:	growth hormone-releasing hormone receptor; GRF receptor; GHRH receptor
UniProt Protein Name:	Growth hormone-releasing hormone receptor
UniProt Synonym Protein Names:	Growth hormone-releasing factor receptor; GRF receptor; GRFR
Protein Family:	Growth hormone-releasing hormone receptor
UniProt Gene Name:	GHRHR
UniProt Entry Name:	GHRHR_HUMAN

Anti-GHRHR Polyclonal Antibody (CAB8421)

Western blot analysis of extracts of various cell lines, using GHRHR antibody (CAB8421) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 15s.

Antibodies

GHRHR Antibody (PACO02781)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)