Anti-GGT5 Antibody (CAB14374)
- SKU:
- CAB14374
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-GGT5 Antibody |
| Antibody SKU: | CAB14374 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 388-587 of human GGT5 (NP_001093251.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HT-29 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 388-587 of human GGT5 (NP_001093251.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TSHV SVLG EDGS AVAA TSTI NTPF GAMV YSPR TGII LNNE LLDL CERC PRGS GTTP SPAV SGDR VGGA PGRC WPPV PGER SPSS MVPS ILIN KAQG SKLV IGGA GGEL IISA VAQA IMSK LWLG FDLR AAIA APIL HVNS KGCV EYEP NFSQ EVQR GLQD RGQN QTQR PFFL NVVQ AVSQ EGAC VYAV SDLR KSGE AAGY |
| Gene ID: | 2687 |
| Uniprot: | P36269 |
| Cellular Location: | Membrane, Single-pass type II membrane protein |
| Calculated MW: | 58kDa/62kDa |
| Observed MW: | 62kDa |
| Synonyms: | GGT5, GGL, GGT 5, GGT-REL, GGTLA1 |
| Background: | This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | GGT5: Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). Belongs to the gamma-glutamyltransferase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.3.2.2; Other Amino Acids Metabolism - selenoamino acid; EC 3.4.19.13; Other Amino Acids Metabolism - taurine and hypotaurine; Transferase; Other Amino Acids Metabolism - glutathione; Membrane protein, integral; Other Amino Acids Metabolism - cyanoamino acid; EC 3.4.19.14; Lipid Metabolism - arachidonic acid Chromosomal Location of Human Ortholog: 22q11.23 Cellular Component: anchored to external side of plasma membrane; plasma membrane Molecular Function:gamma-glutamyltransferase activity Biological Process: amino acid metabolic process; glutathione metabolic process; leukotriene biosynthetic process; leukotriene metabolic process |
| NCBI Summary: | This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014] |
| UniProt Code: | P36269 |
| NCBI GenInfo Identifier: | 116242493 |
| NCBI Gene ID: | 2687 |
| NCBI Accession: | P36269.2 |
| UniProt Secondary Accession: | P36269,Q53XM9, Q6GMP0, Q96FC1, Q9UFM5, |
| UniProt Related Accession: | P36269 |
| Molecular Weight: | 62,332 Da |
| NCBI Full Name: | Gamma-glutamyltransferase 5 |
| NCBI Synonym Full Names: | gamma-glutamyltransferase 5 |
| NCBI Official Symbol: | GGT5 |
| NCBI Official Synonym Symbols: | GGL; GGT 5; GGTLA1; GGT-REL |
| NCBI Protein Information: | gamma-glutamyltransferase 5 |
| UniProt Protein Name: | Gamma-glutamyltransferase 5 |
| UniProt Synonym Protein Names: | Gamma-glutamyl transpeptidase-related enzyme; GGT-rel |
| Protein Family: | Gamma-glutamyltransferase |
| UniProt Gene Name: | GGT5 |
| UniProt Entry Name: | GGT5_HUMAN |
 | Western blot analysis of extracts of HT-29 cells, using GGT5 antibody (CAB14374) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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