Anti-GFRA3 Antibody (CAB2955)
- SKU:
- CAB2955
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-GFRA3 Antibody |
| Antibody SKU: | CAB2955 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-240 of human GFRA3 (NP_001487.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, BxPC-3, HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-240 of human GFRA3 (NP_001487.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DPLP TESR LMNS CLQA RRKC QADP TCSA AYHH LDSC TSSI STPL PSEE PSVP ADCL EAAQ QLRN SSLI GCMC HRRM KNQV ACLD IYWT VHRA RSLG NYEL DVSP YEDT VTSK PWKM NLSK LNML KPDS DLCL KFAM LCTL NDKC DRLR KAYG EACS GPHC QRHV CLRQ LLTF FEKA AEPH AQGL LLCP CAPN DRGC GERR RNTI APNC A |
| Gene ID: | 2676 |
| Uniprot: | O60609 |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor |
| Calculated MW: | 40kDa/44kDa |
| Observed MW: | 45kDa |
| Synonyms: | GFRA3, GDNFR3 |
| Background: | The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. |
| UniProt Protein Function: | GFRA3: Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. Belongs to the GDNFR family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 5q31.1-q31.3 Cellular Component: extrinsic to membrane; intracellular membrane-bound organelle; cytoplasm; plasma membrane; external side of plasma membrane Molecular Function:axon guidance receptor activity; receptor binding Biological Process: axon guidance; nervous system development; sympathetic nervous system development; neuron migration; signal transduction; peripheral nervous system development |
| NCBI Summary: | The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60609 |
| NCBI GenInfo Identifier: | 50403696 |
| NCBI Gene ID: | 2676 |
| NCBI Accession: | O60609.2 |
| UniProt Related Accession: | O60609 |
| Molecular Weight: | Observed Molecular Weight: (Observed)44kD.Predicted Molecular Weight: (Calculated)45kDa. |
| NCBI Full Name: | GDNF family receptor alpha-3 |
| NCBI Synonym Full Names: | GDNF family receptor alpha 3 |
| NCBI Official Symbol: | GFRA3 |
| NCBI Official Synonym Symbols: | GDNFR3 |
| NCBI Protein Information: | GDNF family receptor alpha-3 |
| UniProt Protein Name: | GDNF family receptor alpha-3 |
| Protein Family: | GDNF family receptor |
| UniProt Gene Name: | GFRA3 |
| UniProt Entry Name: | GFRA3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GFRA3 antibody (CAB2955) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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